Research output per year
Research output per year
- 1 - 50 out of 231 results
Search results
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2022
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
Schmitt, M., Ceteci, F., Gupta, J., Pesic, M., Böttger, T. W., Nicolas, A. M., Kennel, K. B., Engel, E., Schewe, M., Callak Kirisözü, A., Petrocelli, V., Dabiri, Y., Varga, J., Ramakrishnan, M., Karimova, M., Ablasser, A., Sato, T., Arkan, M. C., de Sauvage, F. J. & Greten, F. R., 2022 Dec 8, In: Nature. 612, 7939, p. 347-353 7 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium
Oda, M., Hatano, Y. & Sato, T., 2022 Oct, In: Current Opinion in Genetics and Development. 76, 101977.Research output: Contribution to journal › Review article › peer-review
2 Citations (Scopus) -
In Vivo Intestinal Research Using Organoid Transplantation
Sugimoto, S., Kobayashi, E., Kanai, T. & Sato, T., 2022, In: Keio Journal of Medicine. 71, 4, p. 73-81 9 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Microfluidic Device to Manipulate 3D Human Epithelial Cell-Derived Intestinal Organoids
Matsumoto, M., Morimoto, Y., Sato, T. & Takeuchi, S., 2022 Dec, In: Micromachines. 13, 12, 2082.Research output: Contribution to journal › Article › peer-review
Open Access -
Organoid Medicine for Inflammatory Bowel Disease
Wakisaka, Y., Sugimoto, S. & Sato, T., 2022 Feb, In: Stem Cells. 40, 2, p. 123-132 10 p.Research output: Contribution to journal › Review article › peer-review
6 Citations (Scopus) -
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer
Toshimitsu, K., Takano, A., Fujii, M., Togasaki, K., Matano, M., Takahashi, S., Kanai, T. & Sato, T., 2022 Jun, In: Nature Chemical Biology. 18, 6, p. 605-614 10 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Organoid vs In Vivo Mouse Model: Which is Better Research Tool to Understand the Biologic Mechanisms of Intestinal Epithelium?
Sugimoto, S. & Sato, T., 2022 Jan, In: CMGH. 13, 1, p. 195-197 3 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access10 Citations (Scopus) -
2021
Analysis of risk factors for immune-related adverse events in various solid tumors using real-world data
Shimozaki, K., Sukawa, Y., Sato, Y., Horie, S., Chida, A., Tsugaru, K., Togasaki, K., Kawasaki, K., Hirata, K., Hayashi, H., Hamamoto, Y. & Kanai, T., 2021 Jul, In: Future Oncology. 17, 20, p. 2593-2603 11 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
An organoid-based organ-repurposing approach to treat short bowel syndrome
Sugimoto, S., Kobayashi, E., Fujii, M., Ohta, Y., Arai, K., Matano, M., Ishikawa, K., Miyamoto, K., Toshimitsu, K., Takahashi, S., Nanki, K., Hakamata, Y., Kanai, T. & Sato, T., 2021 Apr 1, In: Nature. 592, 7852, p. 99-104 6 p.Research output: Contribution to journal › Article › peer-review
71 Citations (Scopus) -
COVID-19 reinfection: A rapid systematic review of case reports and case series
Wang, J., Kaperak, C., Sato, T. & Sakuraba, A., 2021 Aug 1, In: Journal of Investigative Medicine. 69, 6, p. 1253-1255 3 p.Research output: Contribution to journal › Review article › peer-review
69 Citations (Scopus) -
Demarcated redness associated with increased vascular density/size: A useful marker of flat-type dysplasia in patients with ulcerative colitis
Ikebata, A., Shimoda, M., Okabayashi, K., Uraoka, T., Maehata, T., Sugimoto, S., Mutaguchi, M., Naganuma, M., Kameyama, K., Yahagi, N., Kanai, T., Kitagawa, Y., Kanai, Y. & Iwao, Y., 2021 Apr 1, In: Endoscopy International Open. 9, 4, p. E552-E561Research output: Contribution to journal › Article › peer-review
Open Access -
Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis
Horisawa-Takada, Y., Kodera, C., Takemoto, K., Sakashita, A., Horisawa, K., Maeda, R., Shimada, R., Usuki, S., Fujimura, S., Tani, N., Matsuura, K., Akiyama, T., Suzuki, A., Niwa, H., Tachibana, M., Ohba, T., Katabuchi, H., Namekawa, S. H., Araki, K. & Ishiguro, K. I., 2021 Dec 1, In: Nature communications. 12, 1, 3184.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
Phenotypic screening system using three-dimensional (3D) culture models for natural product screening
Suenaga, H., Kagaya, N., Kawada, M., Tatsuda, D., Sato, T. & Shin-ya, K., 2021 Oct, In: Journal of Antibiotics. 74, 10, p. 660-666 7 p.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus) -
Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases
Fujii, M. & Sato, T., 2021 Feb, In: Nature Materials. 20, 2, p. 156-169 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access81 Citations (Scopus) -
Synthetic mRNA-based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease-induced pluripotent stem cells
Akiyama, T., Sato, S., Ko, S. B. H., Sano, O., Sato, S., Saito, M., Nagai, H., Ko, M. S. H. & Iwata, H., 2021 Apr, In: Stem Cells Translational Medicine. 10, 4, p. 572-581 10 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function
Makino, K., Shimizu-Hirota, R., Goda, N., Hashimoto, M., Kawada, I., Kashiwagi, K., Hirota, Y., Itoh, H., Jinzaki, M., Iwao, Y., Ko, M., Ko, S. & Takaishi, H., 2021 Dec, In: Scientific reports. 11, 1, 15954.Research output: Contribution to journal › Article › peer-review
Open Access -
Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer
Togasaki, K., Sugimoto, S., Ohta, Y., Nanki, K., Matano, M., Takahashi, S., Fujii, M., Kanai, T. & Sato, T., 2021 Feb, In: Gastroenterology. 160, 3, p. 823-830 8 p.Research output: Contribution to journal › Short survey › peer-review
Open Access32 Citations (Scopus) -
2020
A microfluidic organoid trapping device to form tube-like intestinal organoids
Matsumoto, M., Morimoto, Y., Sato, T. & Takeuchi, S., 2020, MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 871-872 2 p. (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine
Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., Mori, Y. & Ohteki, T., 2020 Dec 1, In: Scientific reports. 10, 1, 8308.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma
Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 Feb, In: Gastroenterology. 158, 3, p. 638-651.e8Research output: Contribution to journal › Article › peer-review
44 Citations (Scopus) -
Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells
Tanosaki, S., Tohyama, S., Fujita, J., Someya, S., Hishiki, T., Matsuura, T., Nakanishi, H., Ohto-Nakanishi, T., Akiyama, T., Morita, Y., Kishino, Y., Okada, M., Tani, H., Soma, Y., Nakajima, K., Kanazawa, H., Sugimoto, M., Ko, M., Suematsu, M. & Fukuda, K., 2020 Sept 25, In: iScience. 23, 9, 101535.Research output: Contribution to journal › Article › peer-review
Open Access38 Citations (Scopus) -
Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors
Nakatake, Y., Ko, S. B. H., Sharov, A. A., Wakabayashi, S., Murakami, M., Sakota, M., Chikazawa, N., Ookura, C., Sato, S., Ito, N., Ishikawa-Hirayama, M., Mak, S. S., Jakt, L. M., Ueno, T., Hiratsuka, K., Matsushita, M., Goparaju, S. K., Akiyama, T., Ishiguro, K. I., Oda, M., & 7 others, 2020 May 19, In: Cell Reports. 31, 7, 107655.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
Linking human intestinal scaffolds and organoids to combat intestinal failure
Fujii, M., Sugimoto, S. & Sato, T., 2020 Oct 1, In: Nature medicine. 26, 10, p. 1517-1518 2 p.Research output: Contribution to journal › Comment/debate › peer-review
3 Citations (Scopus) -
MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells
Ishiguro, K. I., Matsuura, K., Tani, N., Takeda, N., Usuki, S., Yamane, M., Sugimoto, M., Fujimura, S., Hosokawa, M., Chuma, S., Ko, M. S. H., Araki, K. & Niwa, H., 2020 Feb 24, In: Developmental Cell. 52, 4, p. 429-445.e10Research output: Contribution to journal › Article › peer-review
Open Access82 Citations (Scopus) -
Multiple immune-related adverse events and anti-tumor efficacy: Real-world data on various solid tumors
Shimozaki, K., Sukawa, Y., Beppu, N., Kurihara, I., Suzuki, S., Mizuno, R., Funakoshi, T., Ikemura, S., Tsugaru, K., Togasaki, K., Kawasaki, K., Hirata, K., Hayashi, H., Hamamoto, Y., Takaishi, H. & Kanai, T., 2020, In: Cancer Management and Research. 12, p. 4585-4593 9 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Citations (Scopus) -
Of infliximab with long-term administration in Japanese patients with Crohn's disease: Analysis using population pharmacokinetics
Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Nagauma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2020, In: International journal of clinical pharmacology and therapeutics. 58, 2, p. 89-102 14 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Organoid derivation and orthotopic xenotransplantation for studying human intestinal stem cell dynamics
Sugimoto, S., Fujii, M. & Sato, T., 2020, Methods in Molecular Biology. Humana Press Inc., p. 303-320 18 p. (Methods in Molecular Biology; vol. 2171).Research output: Chapter in Book/Report/Conference proceeding › Chapter
6 Citations (Scopus) -
Racial disparities in COVID-19 deaths reveal harsh truths about structural inequality in America
Anyane-Yeboa, A., Sato, T. & Sakuraba, A., 2020 Oct 1, In: Journal of Internal Medicine. 288, 4, p. 479-480 2 p.Research output: Contribution to journal › Letter › peer-review
Open Access55 Citations (Scopus) -
Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages
Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., Yamamoto, K., Kitagaki, K., Akashi, T., Okamoto, R. & Ohteki, T., 2020 Aug 1, In: Nature Cell Biology. 22, 8, p. 919-926 8 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
2019
Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia
Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 May 16, In: Oncogene. 38, 20, p. 3962-3969 8 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
Difference in the clinical characteristic and prognosis of colitis-associated cancer and sporadic neoplasia in ulcerative colitis patients
Mutaguchi, M., Naganuma, M., Sugimoto, S., Fukuda, T., Nanki, K., Mizuno, S., Hosoe, N., Shimoda, M., Ogata, H., Iwao, Y. & Kanai, T., 2019 Sept, In: Digestive and Liver Disease. 51, 9, p. 1257-1264 8 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression
Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M. S. H., Tada, N., Okano, H. & Akamatsu, W., 2019 Feb 12, In: Stem cell reports. 12, 2, p. 305-318 14 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors
Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S., Itoh, H. & Ko, M., 2019 Dec 1, In: Scientific reports. 9, 1, 913.Research output: Contribution to journal › Article › peer-review
Open Access32 Citations (Scopus) -
Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative colitis-associated high-grade dysplasia
Sugimoto, S., Shimoda, M., Iwao, Y., Mutaguchi, M., Nanki, K., Mizuno, S., Kameyama, K., Ogata, H., Naganuma, M. & Kanai, T., 2019 Nov 1, In: Digestive Endoscopy. 31, 6, p. 706-711 6 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN
Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019, In: eNeuro. 6, 5, ENEURO.0403-18.2019.Research output: Contribution to journal › Article › peer-review
Open Access37 Citations (Scopus) -
Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine
Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M., & 5 others, 2019 Oct 1, In: Journal of Gastroenterology and Hepatology (Australia). 34, 10, p. 1751-1757 7 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids
Fujii, M., Clevers, H. & Sato, T., 2019 Feb, In: Gastroenterology. 156, 3, p. 562-576 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access83 Citations (Scopus) -
2018
Advancing Intestinal Organoid Technology Toward Regenerative Medicine
Nakamura, T. & Sato, T., 2018, In: CMGH. 5, 1, p. 51-60 10 p.Research output: Contribution to journal › Review article › peer-review
82 Citations (Scopus) -
Clinical efficacy of immune checkpoint inhibitors in the treatment of unresectable advanced or recurrent gastric cancer: An evidence-based review of therapies
Togasaki, K., Sukawa, Y., Kanai, T. & Takaishi, H., 2018, In: OncoTargets and Therapy. 11, p. 8239-8250 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access29 Citations (Scopus) -
Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing
Akiyama, T., Sato, S., Chikazawa-Nohtomi, N., Soma, A., Kimura, H., Wakabayashi, S., Ko, S. B. H. & Ko, M. S. H., 2018 Dec 1, In: Scientific reports. 8, 1, 1189.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
Erratum to: Efficient genetic engineering of human intestinal organoids using electroporation (Nature Protocols, (2015), 10, 10, (1474-1485), 10.1038/nprot.2015.088)
Fujii, M., Matano, M., Nanki, K. & Sato, T., 2018 Jan 1, (Accepted/In press) In: Nature Protocols.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors 10 Technology 1004 Medical Biotechnology
Ida, H., Akiyama, T., Ishiguro, K., Goparaju, S. K., Nakatake, Y., Chikazawa-Nohtomi, N., Sato, S., Kimura, H., Yokoyama, Y., Nagino, M., Ko, M. S. H. & Ko, S. B. H., 2018 Oct 25, In: Stem Cell Research and Therapy. 9, 1, 277.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease
Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 Oct, In: PloS one. 13, 10, e0204632.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Reconstruction of the Human Colon Epithelium In Vivo
Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 Feb 1, In: Cell stem cell. 22, 2, p. 171-176.e5Research output: Contribution to journal › Article › peer-review
124 Citations (Scopus) -
The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy
Nakamoto, F. K., Okamoto, S., Mitsui, J., Sone, T., Ishikawa, M., Yamamoto, Y., Kanegae, Y., Nakatake, Y., Imaizumi, K., Ishiura, H., Tsuji, S. & Okano, H., 2018 Dec 1, In: Scientific reports. 8, 1, 14215.Research output: Contribution to journal › Article › peer-review
Open Access40 Citations (Scopus) -
2017
Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium
Yamaguchi, M., Steward, M. C., Smallbone, K., Sohma, Y., Yamamoto, A., Ko, S. B. H., Kondo, T. & Ishiguro, H., 2017 Mar 15, In: Journal of Physiology. 595, 6, p. 1947-1972 26 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Citations (Scopus) -
Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes
Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., & 19 others, 2017 May 1, In: Nature Cell Biology. 19, 5, p. 530-541 12 p.Research output: Contribution to journal › Article › peer-review
137 Citations (Scopus) -
Defining the role of Lgr5+ stem cells in colorectal cancer: From basic research to clinical applications
Fujii, M. & Sato, T., 2017 Jul 18, In: Genome Medicine. 9, 1, 66.Research output: Contribution to journal › Comment/debate › peer-review
7 Citations (Scopus) -
Endoscopic morphologic features of ulcerative colitis–associated dysplasia classified according to the SCENIC consensus statement
Sugimoto, S., Naganuma, M., Iwao, Y., Matsuoka, K., Shimoda, M., Mikami, S., Mizuno, S., Nakazato, Y., Nanki, K., Inoue, N., Ogata, H. & Kanai, T., 2017 Mar 1, In: Gastrointestinal Endoscopy. 85, 3, p. 639-646.e2Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells
Akiyama, T., Wakabayashi, S., Soma, A., Sato, S., Nakatake, Y., Oda, M., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S. & Ko, M. S. H., 2017, In: Stem Cells International. 2017, 7215010.Research output: Contribution to journal › Review article › peer-review
5 Citations (Scopus)