TY - JOUR
T1 - α-Synuclein aggregation in the olfactory bulb of middle-aged common marmoset
AU - Kobayashi, Reona
AU - Takahashi-Fujigasaki, Junko
AU - Shiozawa, Seiji
AU - Hara-Miyauchi, Chikako
AU - Inoue, Takashi
AU - Okano, Hirotaka James
AU - Sasaki, Erika
AU - Okano, Hideyuki
N1 - Funding Information:
This work was supported by fundings from Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) and “Construction of System for Spread of Primate Model Animals” (to H.O., E.S.) carried out under the Strategic Research Program for Brain Science from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT) and Japan Agency for Medical Research and Development (A-MED) , and Scientific Research on Innovative Area , a MEXT Grant-in-Aid Project FY2014-2018 “Brain Protein Aging and Dementia Control” (to H.O.). This work was also supported by grants of the “Innovative approaches for the compilation of non-human primate brain map” carried out under the Brain/MINDS from MEXT and A-MED to E.S.
Publisher Copyright:
© 2015 Published by Elsevier Ireland Ltd.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - The synaptic protein α-synuclein has been identified as a major component of Lewy bodies, a pathological hallmark of Parkinson's disease (PD). Prior to the formation of Lewy bodies, mislocalization and aggregation of the α-synuclein in brain tissue is frequently observed in various neurodegenerative diseases. Aberrant accumulation and localization of α-synuclein are also observed in the aging human brain, for which reason aging is regarded as a risk factor for neurodegenerative disease. To investigate changes in α-synuclein properties in the aging brain, we compared α-synuclein immunoreactivity in brain tissue of young (2-years-old) and middle-aged (6-years-old) common marmoset (Callithrix jacchus). Our analyses revealed marked changes in α-synuclein immunoreactivity in the olfactory bulb of common marmosets of these age cohorts. Perikaryal α-synuclein aggregations were formed in the olfactory bulb in middle-aged animals. We also observed signals of α-synuclein accumulation in hippocampus in this cohort; however, unlike in the olfactory bulb, hippocampal α-synuclein signals were localized in the synaptic terminals. We did not observe either of these features in younger marmosets, which suggest that aging may play a role in these phenomena.Our results using common marmoset brain corresponded with the observation that the α-synuclein aggregations were first occurred from olfactory bulb in human normal aged and PD brain. Therefore, common marmoset is expected as useful model for α-synuclein pathology.
AB - The synaptic protein α-synuclein has been identified as a major component of Lewy bodies, a pathological hallmark of Parkinson's disease (PD). Prior to the formation of Lewy bodies, mislocalization and aggregation of the α-synuclein in brain tissue is frequently observed in various neurodegenerative diseases. Aberrant accumulation and localization of α-synuclein are also observed in the aging human brain, for which reason aging is regarded as a risk factor for neurodegenerative disease. To investigate changes in α-synuclein properties in the aging brain, we compared α-synuclein immunoreactivity in brain tissue of young (2-years-old) and middle-aged (6-years-old) common marmoset (Callithrix jacchus). Our analyses revealed marked changes in α-synuclein immunoreactivity in the olfactory bulb of common marmosets of these age cohorts. Perikaryal α-synuclein aggregations were formed in the olfactory bulb in middle-aged animals. We also observed signals of α-synuclein accumulation in hippocampus in this cohort; however, unlike in the olfactory bulb, hippocampal α-synuclein signals were localized in the synaptic terminals. We did not observe either of these features in younger marmosets, which suggest that aging may play a role in these phenomena.Our results using common marmoset brain corresponded with the observation that the α-synuclein aggregations were first occurred from olfactory bulb in human normal aged and PD brain. Therefore, common marmoset is expected as useful model for α-synuclein pathology.
KW - Common marmoset
KW - Olfactory bulb
KW - Parkinson's disease
KW - α-Synuclein
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U2 - 10.1016/j.neures.2015.11.006
DO - 10.1016/j.neures.2015.11.006
M3 - Article
C2 - 26643383
AN - SCOPUS:84954288058
SN - 0168-0102
VL - 106
SP - 55
EP - 61
JO - Neuroscience Research
JF - Neuroscience Research
ER -
