κ-Opioid agonist inhibits phospholipase C, possibly via an inhibition of G-protein activity

Hidemi Misawa; Hiroshi Ueda; Masamichi Satoh

doi:10.1016/0304-3940(90)90224-W

κ-Opioid agonist inhibits phospholipase C, possibly via an inhibition of G-protein activity

Hidemi Misawa, Hiroshi Ueda, Masamichi Satoh

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

In synaptic membranes of guinea pig cerebellum, in which preparations U-50, 488H, a κ-opioid agonist inhibits G-protein activity, the same κ-agonist at 100 nM inhibited the phospholipase C (PLC) activity stimulated by 100 μM GTP in the presence of 10 μM Ca²⁺. The present study provides a unique hypothetical mechanism that the receptor-mediated inhibition of PLC is mediated by inhibition of G-protein activity.

Original language	English
Pages (from-to)	324-327
Number of pages	4
Journal	Neuroscience Letters
Volume	112
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3940(90)90224-W
Publication status	Published - 1990 May 4
Externally published	Yes

Keywords

GTP-binding protein
Phospholipase C
κ-Opioid receptor

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(90)90224-W

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title = "κ-Opioid agonist inhibits phospholipase C, possibly via an inhibition of G-protein activity",

abstract = "In synaptic membranes of guinea pig cerebellum, in which preparations U-50, 488H, a κ-opioid agonist inhibits G-protein activity, the same κ-agonist at 100 nM inhibited the phospholipase C (PLC) activity stimulated by 100 μM GTP in the presence of 10 μM Ca2+. The present study provides a unique hypothetical mechanism that the receptor-mediated inhibition of PLC is mediated by inhibition of G-protein activity.",

keywords = "GTP-binding protein, Phospholipase C, κ-Opioid receptor",

author = "Hidemi Misawa and Hiroshi Ueda and Masamichi Satoh",

year = "1990",

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doi = "10.1016/0304-3940(90)90224-W",

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pages = "324--327",

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T1 - κ-Opioid agonist inhibits phospholipase C, possibly via an inhibition of G-protein activity

AU - Misawa, Hidemi

AU - Ueda, Hiroshi

AU - Satoh, Masamichi

PY - 1990/5/4

Y1 - 1990/5/4

N2 - In synaptic membranes of guinea pig cerebellum, in which preparations U-50, 488H, a κ-opioid agonist inhibits G-protein activity, the same κ-agonist at 100 nM inhibited the phospholipase C (PLC) activity stimulated by 100 μM GTP in the presence of 10 μM Ca2+. The present study provides a unique hypothetical mechanism that the receptor-mediated inhibition of PLC is mediated by inhibition of G-protein activity.

AB - In synaptic membranes of guinea pig cerebellum, in which preparations U-50, 488H, a κ-opioid agonist inhibits G-protein activity, the same κ-agonist at 100 nM inhibited the phospholipase C (PLC) activity stimulated by 100 μM GTP in the presence of 10 μM Ca2+. The present study provides a unique hypothetical mechanism that the receptor-mediated inhibition of PLC is mediated by inhibition of G-protein activity.

KW - GTP-binding protein

KW - Phospholipase C

KW - κ-Opioid receptor

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U2 - 10.1016/0304-3940(90)90224-W

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SN - 0304-3940

VL - 112

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EP - 327

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2-3

ER -

κ-Opioid agonist inhibits phospholipase C, possibly via an inhibition of G-protein activity

Abstract

Keywords

ASJC Scopus subject areas

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