12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity

Taiko Oda; Jinzhong Xu; Kazuyo Ukai; Takahiro Nakazawa; Michio Namikoshi

doi:10.1007/s10267-010-0035-x

12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity

Taiko Oda
, Jinzhong Xu
, Kazuyo Ukai
, Takahiro Nakazawa
, Michio Namikoshi

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Roridin E is a well-known macrocyclic trichothecene mycotoxin possessing potent antiproliferative activity against cancer cell lines. 12′-Hydroxyroridin E was isolated from a marine-derived fungus, Myrothecium roridum 98F42. The cytotoxicities of these two compounds were tested against human monocytic THP-1, human promyelocytic leukemia HL-60, and Chinese hamster V79 cells, and roridin E exhibited more than 1000-fold stronger cytotoxicity than its 12′-OH derivative; therefore, it was suggested that the 12′-position is closely involved in the cytotoxicity of these compounds.

Original language	English
Pages (from-to)	317-320
Number of pages	4
Journal	Mycoscience
Volume	51
Issue number	4
DOIs	https://doi.org/10.1007/s10267-010-0035-x
Publication status	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 14 Life Below Water

Keywords

12′-Hydroxyroridin E
HL-60
Marine-derived fungus
Myrothecium roridum
THP-1

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics

Access to Document

10.1007/s10267-010-0035-x

Cite this

@article{e1fd5d0ce35543219ab89033faacbcbc,

title = "12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity",

abstract = "Roridin E is a well-known macrocyclic trichothecene mycotoxin possessing potent antiproliferative activity against cancer cell lines. 12′-Hydroxyroridin E was isolated from a marine-derived fungus, Myrothecium roridum 98F42. The cytotoxicities of these two compounds were tested against human monocytic THP-1, human promyelocytic leukemia HL-60, and Chinese hamster V79 cells, and roridin E exhibited more than 1000-fold stronger cytotoxicity than its 12′-OH derivative; therefore, it was suggested that the 12′-position is closely involved in the cytotoxicity of these compounds.",

keywords = "12′-Hydroxyroridin E, HL-60, Marine-derived fungus, Myrothecium roridum, THP-1",

author = "Taiko Oda and Jinzhong Xu and Kazuyo Ukai and Takahiro Nakazawa and Michio Namikoshi",

note = "Funding Information: Acknowledgments This work was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas 17035029 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan to M. N. We thank Ms. M. Endo and A. Fujita for their excellent technical assistance.",

year = "2010",

doi = "10.1007/s10267-010-0035-x",

language = "English",

volume = "51",

pages = "317--320",

journal = "Mycoscience",

issn = "1340-3540",

publisher = "The Mycological Society of Japan",

number = "4",

}

TY - JOUR

T1 - 12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity

AU - Oda, Taiko

AU - Xu, Jinzhong

AU - Ukai, Kazuyo

AU - Nakazawa, Takahiro

AU - Namikoshi, Michio

N1 - Funding Information: Acknowledgments This work was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas 17035029 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan to M. N. We thank Ms. M. Endo and A. Fujita for their excellent technical assistance.

PY - 2010

Y1 - 2010

N2 - Roridin E is a well-known macrocyclic trichothecene mycotoxin possessing potent antiproliferative activity against cancer cell lines. 12′-Hydroxyroridin E was isolated from a marine-derived fungus, Myrothecium roridum 98F42. The cytotoxicities of these two compounds were tested against human monocytic THP-1, human promyelocytic leukemia HL-60, and Chinese hamster V79 cells, and roridin E exhibited more than 1000-fold stronger cytotoxicity than its 12′-OH derivative; therefore, it was suggested that the 12′-position is closely involved in the cytotoxicity of these compounds.

AB - Roridin E is a well-known macrocyclic trichothecene mycotoxin possessing potent antiproliferative activity against cancer cell lines. 12′-Hydroxyroridin E was isolated from a marine-derived fungus, Myrothecium roridum 98F42. The cytotoxicities of these two compounds were tested against human monocytic THP-1, human promyelocytic leukemia HL-60, and Chinese hamster V79 cells, and roridin E exhibited more than 1000-fold stronger cytotoxicity than its 12′-OH derivative; therefore, it was suggested that the 12′-position is closely involved in the cytotoxicity of these compounds.

KW - 12′-Hydroxyroridin E

KW - HL-60

KW - Marine-derived fungus

KW - Myrothecium roridum

KW - THP-1

UR - https://www.scopus.com/pages/publications/77954243398

UR - https://www.scopus.com/pages/publications/77954243398#tab=citedBy

U2 - 10.1007/s10267-010-0035-x

DO - 10.1007/s10267-010-0035-x

M3 - Article

AN - SCOPUS:77954243398

SN - 1340-3540

VL - 51

SP - 317

EP - 320

JO - Mycoscience

JF - Mycoscience

IS - 4

ER -

12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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