A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration

Yuri Sano, Hiroshi Satoh, Momoko Chiba, Atsuko Shinohara, Masahide Okamoto, Koji Serizawa, Hiroshi Nakashima, Kazuyuki Omae

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Although bismuth is widely used as a lead substitute in the industrial field, the toxicity of bismuth by inhalation is little known. We performed a 13-wk intratracheal intermittent bismuth dose toxicity study. Bismuth was administered at dose levels of 0, 0.8, 4, 20 mg/kg to male Crj:CD(SD)IGS rats (SPF) by intratracheal intermittent administration once a week for thirteen weeks to investigate its potential toxic effects; especially for specific adverse effects and changes related to pre-neoplastic lesions. Our results showed foreign body inflammation in the lungs, which was caused by intratracheal administration of bismuth, and physical changes related to pulmonary lesions; however, there were no serious changes in other organs. We concluded that dose-dependent, but not specific adverse effects, were attributable to bismuth inhalation in the rat.

Original languageEnglish
Pages (from-to)242-248
Number of pages7
JournalJournal of occupational health
Issue number3
Publication statusPublished - 2005 May
Externally publishedYes


  • Bismuth
  • Intratracheal administration
  • Lead-free solder
  • Rat
  • Subchronic toxicity

ASJC Scopus subject areas

  • Medicine(all)


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