A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells

Masanori Sakaguchi, Tetsuro Shingo, Takuya Shimazaki, Hirotaka James Okano, Mieko Shiwa, Satoru Ishibashi, Hideyuki Oguro, Mikiko Ninomiya, Toshihiko Kadoya, Hidenori Horie, Akira Shibuya, Hidehiro Mizusawa, Françoise Poirier, Hiromitsu Nakauchi, Kazunobu Sawamoto, Hideyuki Okano

Research output: Contribution to journalArticlepeer-review

146 Citations (Scopus)


In the subventricular zone of the adult mammalian forebrain, neural stem cells (NSCs) reside and proliferate to generate young neurons. We screened factors that promoted the proliferation of NSCs in vitro by a recently developed proteomics technique, the ProteinChip system. In this screen, we identified a soluble carbohydrate-binding protein, Galectin-1, as a candidate. We show herein that Galectin-1 is expressed in a subset of slowly dividing subventricular zone astrocytes, which includes the NSCs. Based on results from intraventricular infusion experiments and phenotypic analyses of knockout mice, we demonstrate that Galectin-1 is an endogenous factor that promotes the proliferation of NSCs in the adult brain.

Original languageEnglish
Pages (from-to)7112-7117
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number18
Publication statusPublished - 2006 May 2


  • Lectin
  • Mobilization
  • Stem cell niche

ASJC Scopus subject areas

  • General


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