A case of blastic plasmacytoid dendritic cell neoplasm involving the skin

Shota Fukuoka, Yoshitaka Miyakawa, Takahiro Suzuki, Rie Irie, Yuichi Kurihara, Hiroshi Okano, Satoshi Akizuki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A 81 year-old male patient visited our hospital on February, 2011 because he found the subcutaneous tumor on his back. The dermatologist performed skin biopsy and found that large atypical cells diffusely proliferated in the sub-epidermal and subcutaneous tissue. Two month later, we diagnosed him as blastic plasmacytoid dendritic cell tumor, as the blastic cells in the lymph node were CD4+, CD56+, CD3-, CD5-, CD20-, CD138-, MPO-, granzyme B, TCL1+. None of the gene rearrangements of T-cell receptor and immunoglobulin was negative in the lymph node. The tumor was relapsed after 3 courses of COP therapy and the patient failed to respond to the salvage therapies such as CEPP and FMD therapy. As this tumor is rare and there are no standard regimens, we reviewed the past case series and discussed about the pathogenesis, clinical course and treatment options of this tumor in this article.

Original languageEnglish
Pages (from-to)1255-1258
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Issue number9
Publication statusPublished - 2013 Sept
Externally publishedYes


  • Blastic plasmacytoid dendritic cell neoplasm
  • Hematological malignancy
  • TCL1

ASJC Scopus subject areas

  • Medicine(all)


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