A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult

Hiroshi Nishihara, Yoshimaru Ozaki, Tamio Ito, Tomoaki Yoshinaga, Kouichi Tabu, Mishie Tanino, Kazuo Nagashima, Shinya Tanaka

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Central nervous system (CNS) neuroblastoma/ganglioneuroblastoma is one of the embryonal tumors with neuronal differentiation found in young adults, but it is most common in children, especially in those below the age of 5 years, whereas extraventricular neurocytoma, a rare neuroepithelial tumor with neuronal differentiation, mostly affects young adults. Here we present a rare case of cerebral ganglioneuronal tumor that occurred in a 32-year-old woman. The patient suffered from tonic convulsion, and computed tomography demonstrated a well-demarcated, round tumor 3.3 cm in size with marked calcification in the right parietal lobe. Histological analysis revealed diffuse infiltration of small, round cells with scattered large ganglion-like cells. Immunohistochemically, the tumor cells did not react with any neuronal molecules, except for chromogranin A in ganglion-like large tumor cells, but electron microscopy demonstrated the presence of synapse-like nerve terminal structures without mature postsynaptic density, suggesting the presence of neoplastic tumor components with neuronal differentiation; thus, this tumor was diagnosed as CNS ganglioneuroblastoma with possible low-grade malignancy because the Mib-1 labeling index was less than 3%-4%. Here we discuss the histological entity of cerebral ganglioneuronal tumors, including extraventricular neurocytoma.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalBrain tumor pathology
Issue number1
Publication statusPublished - 2008
Externally publishedYes


  • Electron microscope
  • Extraventricular neurocytoma
  • Ganglioneuroblastoma
  • Immunohistochemistry

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research


Dive into the research topics of 'A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult'. Together they form a unique fingerprint.

Cite this