A case of diabetic glomerulosclerosis without concurrent diabetes mellitus

Yusuke Jo, Atsuhiro Ichihara, Takashi Eguchi, Isao Kurihara, Akinori Hashiguchi, Konosuke Konishi, Matsuhiko Hayashi, Takao Saruta

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Diabetic nephropathy is a complication of diabetes mellitus that is characterized by the appearance of diffuse and nodular glomerulosclerosis A 46-year-old man presented with generalized edema. He had severe nephrotic syndrome, renal insufficiency and hypertension without a family history or clinical evidence of diabetes mellitus. Oral glucose tolerance test showed impaired glucose tolerance, but several fasting plasma glucose determinations and serum hemoglobin A1c levels were normal. Renal biopsy revealed nodular and diffuse glomerulosclerosis characteristic of diabetic nephropathy. The present case demonstrates that nodular glomerulosclerosis may be present without clinically overt diabetes mellitus.

Original languageEnglish
Pages (from-to)552-557
Number of pages6
JournalJapanese Journal of Nephrology
Issue number7
Publication statusPublished - 2002 Dec 14


  • Diabetes mellitus
  • Hypertension
  • Nephrotic syndrome
  • Nodular glomerulosclerosis

ASJC Scopus subject areas

  • Nephrology


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