A case of duodenal perforation during bevacizumab combination chemotherapy in a patient with multiple lung metastasis after a sigmoidectomy

Hirofumi Suzumura; Hiroharu Shinozaki; Rie Kondo; Masatoshi Yamaguchi; Yukiko Torizaki; Yosuke Ozawa; Yurie Futoh; Tadashi Matsuoka; Kenji Matsumoto; Masazumi Inoue; Yuichi Sasakura; Toshiaki Terauchi; Masaru Kimata; Junji Furukawa; Kenji Kobayashi; Yoshiro Ogata

A case of duodenal perforation during bevacizumab combination chemotherapy in a patient with multiple lung metastasis after a sigmoidectomy

Hirofumi Suzumura, Hiroharu Shinozaki, Rie Kondo, Masatoshi Yamaguchi, Yukiko Torizaki, Yosuke Ozawa, Yurie Futoh, Tadashi Matsuoka, Kenji Matsumoto, Masazumi Inoue, Yuichi Sasakura, Toshiaki Terauchi, Masaru Kimata, Junji Furukawa, Kenji Kobayashi, Yoshiro Ogata

Research output: Contribution to journal › Article › peer-review

Abstract

A 73-year-old man underwent laparoscopic sigmoidectomy for sigmoid colon cancer. Two years after the operation, multiple lung metastasis was diagnosed and chemotherapy with bevacizumab, irinotecan, and TS-1^® was started in the patient. However, epigastric pain developed 73 days after the initial course of chemotherapy. Abdominal CT revealed duodenal perforation and generalized peritonitis. Emergency operation with omental patch closure was immediately performed. The patient was discharged 15 days after the emergency operation without any complication. This is an extremely rare case of bevacizumab-related duodenal perforation.

Original language	English
Pages (from-to)	953-955
Number of pages	3
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	46
Issue number	5
Publication status	Published - 2019 May
Externally published	Yes

Keywords

Bevacizumab
Duodenal perforation

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Suzumura, H., Shinozaki, H., Kondo, R., Yamaguchi, M., Torizaki, Y., Ozawa, Y., Futoh, Y., Matsuoka, T., Matsumoto, K., Inoue, M., Sasakura, Y., Terauchi, T., Kimata, M., Furukawa, J., Kobayashi, K., & Ogata, Y. (2019). A case of duodenal perforation during bevacizumab combination chemotherapy in a patient with multiple lung metastasis after a sigmoidectomy. Japanese Journal of Cancer and Chemotherapy, 46(5), 953-955.

Suzumura, H, Shinozaki, H, Kondo, R, Yamaguchi, M, Torizaki, Y, Ozawa, Y, Futoh, Y, Matsuoka, T, Matsumoto, K, Inoue, M, Sasakura, Y, Terauchi, T, Kimata, M, Furukawa, J, Kobayashi, K & Ogata, Y 2019, 'A case of duodenal perforation during bevacizumab combination chemotherapy in a patient with multiple lung metastasis after a sigmoidectomy', Japanese Journal of Cancer and Chemotherapy, vol. 46, no. 5, pp. 953-955.

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title = "A case of duodenal perforation during bevacizumab combination chemotherapy in a patient with multiple lung metastasis after a sigmoidectomy",

abstract = "A 73-year-old man underwent laparoscopic sigmoidectomy for sigmoid colon cancer. Two years after the operation, multiple lung metastasis was diagnosed and chemotherapy with bevacizumab, irinotecan, and TS-1{\textregistered} was started in the patient. However, epigastric pain developed 73 days after the initial course of chemotherapy. Abdominal CT revealed duodenal perforation and generalized peritonitis. Emergency operation with omental patch closure was immediately performed. The patient was discharged 15 days after the emergency operation without any complication. This is an extremely rare case of bevacizumab-related duodenal perforation.",

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author = "Hirofumi Suzumura and Hiroharu Shinozaki and Rie Kondo and Masatoshi Yamaguchi and Yukiko Torizaki and Yosuke Ozawa and Yurie Futoh and Tadashi Matsuoka and Kenji Matsumoto and Masazumi Inoue and Yuichi Sasakura and Toshiaki Terauchi and Masaru Kimata and Junji Furukawa and Kenji Kobayashi and Yoshiro Ogata",

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language = "English",

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T1 - A case of duodenal perforation during bevacizumab combination chemotherapy in a patient with multiple lung metastasis after a sigmoidectomy

AU - Suzumura, Hirofumi

AU - Shinozaki, Hiroharu

AU - Kondo, Rie

AU - Yamaguchi, Masatoshi

AU - Torizaki, Yukiko

AU - Ozawa, Yosuke

AU - Futoh, Yurie

AU - Matsuoka, Tadashi

AU - Matsumoto, Kenji

AU - Inoue, Masazumi

AU - Sasakura, Yuichi

AU - Terauchi, Toshiaki

AU - Kimata, Masaru

AU - Furukawa, Junji

AU - Kobayashi, Kenji

AU - Ogata, Yoshiro

PY - 2019/5

Y1 - 2019/5

N2 - A 73-year-old man underwent laparoscopic sigmoidectomy for sigmoid colon cancer. Two years after the operation, multiple lung metastasis was diagnosed and chemotherapy with bevacizumab, irinotecan, and TS-1® was started in the patient. However, epigastric pain developed 73 days after the initial course of chemotherapy. Abdominal CT revealed duodenal perforation and generalized peritonitis. Emergency operation with omental patch closure was immediately performed. The patient was discharged 15 days after the emergency operation without any complication. This is an extremely rare case of bevacizumab-related duodenal perforation.

AB - A 73-year-old man underwent laparoscopic sigmoidectomy for sigmoid colon cancer. Two years after the operation, multiple lung metastasis was diagnosed and chemotherapy with bevacizumab, irinotecan, and TS-1® was started in the patient. However, epigastric pain developed 73 days after the initial course of chemotherapy. Abdominal CT revealed duodenal perforation and generalized peritonitis. Emergency operation with omental patch closure was immediately performed. The patient was discharged 15 days after the emergency operation without any complication. This is an extremely rare case of bevacizumab-related duodenal perforation.

KW - Bevacizumab

KW - Duodenal perforation

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SN - 0385-0684

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JF - Japanese Journal of Cancer and Chemotherapy

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ER -

A case of duodenal perforation during bevacizumab combination chemotherapy in a patient with multiple lung metastasis after a sigmoidectomy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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