A case of hypoglycemic hemiparesis and literature review

Tetsuhiro Yoshino, Shu Meguro, Yukie Soeda, Arata Itoh, Toshihide Kawai, Hiroshi Itoh

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


An 89-year-old man with diabetes treated with metformin 500 mg/day and glimepiride 4 mg/day was hospitalized because of hypoglycemic right hemiparesis and dysarthria (casual glucose value 1.8 mmol/L), which resolved quickly following administration of 40 mL of 40% dextrose. Hemiparesis is a rare symptom (4.2%) of hypoglycemia. There are about 200 case reports of hypoglycemic hemiparesis. The average glucose level at which hemiparesis developed was 1.8 mmol/L. Right-sided hemiparesis predominated (R 66%; L 34%). On imaging studies, abnormal findings were frequently observed in the internal capsule or splenium of the corpus callosum. The mechanism of hemiparesis is not fully understood. The existence of cases in which hypoglycemia cannot be distinguished from stroke on imaging studies suggests the importance of measurement of the blood glucose level when the symptoms of stroke are first recognized.

Original languageEnglish
Pages (from-to)347-351
Number of pages5
JournalUpsala Journal of Medical Sciences
Issue number3
Publication statusPublished - 2012 Aug


  • Diabetes
  • glimepiride
  • hypoglycemic hemiparesis
  • magnetic resonance
  • metformin

ASJC Scopus subject areas

  • General Medicine


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