A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission

Yusuke Sakamaki; Matsuhiko Hayashi; Shu Wakino; Seiichi Fukuda; Kounosuke Konishi; Akinori Hashiguchi; Koichi Hayashi; Hiroshi Itoh

doi:10.2169/internalmedicine.50.4020

A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission

Yusuke Sakamaki, Matsuhiko Hayashi, Shu Wakino, Seiichi Fukuda, Kounosuke Konishi, Akinori Hashiguchi, Koichi Hayashi, Hiroshi Itoh

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We report a case of membranous nephropathy with primary biliary cirrhosis (PBC). A 76-year-old Japanese man had been treated for PBC and was referred to our department because of acute severe proteinuria (10 g/day). Renal biopsy was performed and was compatible with a diagnosis of membranous nephropathy. The patient was treated with cyclosporine A (CsA; Neoral®), which was followed by normalization of liver function and partial remission of proteinuria (0.68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC.

Original language	English
Pages (from-to)	233-238
Number of pages	6
Journal	Internal Medicine
Volume	50
Issue number	3
DOIs	https://doi.org/10.2169/internalmedicine.50.4020
Publication status	Published - 2011

Keywords

Cyclosporine
Membranous nephropathy
Nephrotic syndrome
Primary biliary cirrhosis

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.50.4020

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abstract = "We report a case of membranous nephropathy with primary biliary cirrhosis (PBC). A 76-year-old Japanese man had been treated for PBC and was referred to our department because of acute severe proteinuria (10 g/day). Renal biopsy was performed and was compatible with a diagnosis of membranous nephropathy. The patient was treated with cyclosporine A (CsA; Neoral{\textregistered}), which was followed by normalization of liver function and partial remission of proteinuria (0.68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC.",

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AU - Sakamaki, Yusuke

AU - Hayashi, Matsuhiko

AU - Wakino, Shu

AU - Fukuda, Seiichi

AU - Konishi, Kounosuke

AU - Hashiguchi, Akinori

AU - Hayashi, Koichi

AU - Itoh, Hiroshi

PY - 2011

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AB - We report a case of membranous nephropathy with primary biliary cirrhosis (PBC). A 76-year-old Japanese man had been treated for PBC and was referred to our department because of acute severe proteinuria (10 g/day). Renal biopsy was performed and was compatible with a diagnosis of membranous nephropathy. The patient was treated with cyclosporine A (CsA; Neoral®), which was followed by normalization of liver function and partial remission of proteinuria (0.68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC.

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KW - Nephrotic syndrome

KW - Primary biliary cirrhosis

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A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission

Abstract

Keywords

ASJC Scopus subject areas

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