A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis

Hiroya Takeuchi; Ken Futamata; Arafumi Maeshima; Shigemichi Hirose; Atsushi Shimada; Yoshiki Kawaguchi; Jo Tokuyama; Koji Osumi; Shinya Kishi; Takashi Hojo; Shiei Kim; Norihito Wada; Takashi Oishi; Yoh Isobe; Shunji Ikeuchi; Kiyoshi Kubochi; Sumio Matsumoto

doi:10.1385/IJGC:36:2:99

A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis

Hiroya Takeuchi, Ken Futamata, Arafumi Maeshima, Shigemichi Hirose, Atsushi Shimada, Yoshiki Kawaguchi, Jo Tokuyama, Koji Osumi, Shinya Kishi, Takashi Hojo, Shiei Kim, Norihito Wada, Takashi Oishi, Yoh Isobe, Shunji Ikeuchi, Kiyoshi Kubochi, Sumio Matsumoto

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC.

Original language	English
Pages (from-to)	99-104
Number of pages	6
Journal	International Journal of Gastrointestinal Cancer
Volume	36
Issue number	2
DOIs	https://doi.org/10.1385/IJGC:36:2:99
Publication status	Published - 2005 Oct
Externally published	Yes

Keywords

Adenocarcinoma
Lymph node metastasis
Small cell carcinoma
Stomach

ASJC Scopus subject areas

Oncology
Endocrinology
Gastroenterology

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Takeuchi, H., Futamata, K., Maeshima, A., Hirose, S., Shimada, A., Kawaguchi, Y., Tokuyama, J., Osumi, K., Kishi, S., Hojo, T., Kim, S., Wada, N., Oishi, T., Isobe, Y., Ikeuchi, S., Kubochi, K., & Matsumoto, S. (2005). A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis. International Journal of Gastrointestinal Cancer, 36(2), 99-104. https://doi.org/10.1385/IJGC:36:2:99

Takeuchi, H, Futamata, K, Maeshima, A, Hirose, S, Shimada, A, Kawaguchi, Y, Tokuyama, J, Osumi, K, Kishi, S, Hojo, T, Kim, S, Wada, N, Oishi, T, Isobe, Y, Ikeuchi, S, Kubochi, K & Matsumoto, S 2005, 'A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis', International Journal of Gastrointestinal Cancer, vol. 36, no. 2, pp. 99-104. https://doi.org/10.1385/IJGC:36:2:99

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abstract = "We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC.",

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AU - Futamata, Ken

AU - Maeshima, Arafumi

AU - Hirose, Shigemichi

AU - Shimada, Atsushi

AU - Kawaguchi, Yoshiki

AU - Tokuyama, Jo

AU - Osumi, Koji

AU - Kishi, Shinya

AU - Hojo, Takashi

AU - Kim, Shiei

AU - Wada, Norihito

AU - Oishi, Takashi

AU - Isobe, Yoh

AU - Ikeuchi, Shunji

AU - Kubochi, Kiyoshi

AU - Matsumoto, Sumio

PY - 2005/10

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N2 - We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC.

AB - We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC.

KW - Adenocarcinoma

KW - Lymph node metastasis

KW - Small cell carcinoma

KW - Stomach

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A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis

Abstract

Keywords

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