A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient

Daisuke Kubota; Chizuru Takishima; Ken Ishii; Takahiro Kawamura; Tomoko Matsumoto; Yasuhiro Itsui; Eriko Okada; Seishin Chin; Shinya Oooka; Kiichiro Tsuchiya; Akihiro Araki; Naoya Sakamoto; Tatsuya Miyata; Takanori Kanai; Mamoru Watanabe

A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient

Daisuke Kubota, Chizuru Takishima, Ken Ishii, Takahiro Kawamura, Tomoko Matsumoto, Yasuhiro Itsui, Eriko Okada, Seishin Chin, Shinya Oooka, Kiichiro Tsuchiya, Akihiro Araki, Naoya Sakamoto, Tatsuya Miyata, Takanori Kanai, Mamoru Watanabe

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/μl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level.

Original language	English
Pages (from-to)	1044-1049
Number of pages	6
Journal	Japanese Journal of Gastroenterology
Volume	103
Issue number	9
Publication status	Published - 2006 Sept 1
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology

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title = "A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient",

abstract = "A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/μl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level.",

author = "Daisuke Kubota and Chizuru Takishima and Ken Ishii and Takahiro Kawamura and Tomoko Matsumoto and Yasuhiro Itsui and Eriko Okada and Seishin Chin and Shinya Oooka and Kiichiro Tsuchiya and Akihiro Araki and Naoya Sakamoto and Tatsuya Miyata and Takanori Kanai and Mamoru Watanabe",

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T2 - Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient

AU - Kubota, Daisuke

AU - Takishima, Chizuru

AU - Ishii, Ken

AU - Kawamura, Takahiro

AU - Matsumoto, Tomoko

AU - Itsui, Yasuhiro

AU - Okada, Eriko

AU - Chin, Seishin

AU - Oooka, Shinya

AU - Tsuchiya, Kiichiro

AU - Araki, Akihiro

AU - Sakamoto, Naoya

AU - Miyata, Tatsuya

AU - Kanai, Takanori

AU - Watanabe, Mamoru

PY - 2006/9/1

Y1 - 2006/9/1

N2 - A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/μl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level.

AB - A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/μl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level.

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SN - 0446-6586

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JO - Japanese Journal of Gastroenterology

JF - Japanese Journal of Gastroenterology

IS - 9

ER -

A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient

Abstract

ASJC Scopus subject areas

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