A catalytic asymmetric anti-selective nitroaldol reaction with a neodymium-sodium heterobimetallic complex

Tatsuya Nitabaru, Naoya Kumagai, Masakatsu Shibasaki

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85 Citations (Scopus)

Abstract

A catalytic asymmetric anti-selective nitroaldol reaction with a neodymium-sodium heterobimetallic catalyst is described. A readily accessible amide ligand works efficiently as a chiral platform for the Nd/Na heterobimetallic catalyst in the reaction of various aldehydes and nitroethane, affording anti-1,2-nitro alkanols in good diastereo- and enantioselectivity.

Original languageEnglish
Pages (from-to)272-276
Number of pages5
JournalTetrahedron Letters
Volume49
Issue number2
DOIs
Publication statusPublished - 2008 Jan 7
Externally publishedYes

Keywords

  • Asymmetric catalysis
  • Heterobimetallic catalyst
  • Neodymium
  • Nitroaldol (Henry) reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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