TY - GEN
T1 - A centrifuge-based droplet shooting device for the synthesis of multi-compartmental microspheres under ultra-high gravity
AU - Maeda, Kazuki
AU - Takinoue, Masahiro
AU - Onoe, Hiroaki
AU - Takeuchi, Shoji
PY - 2011/12/1
Y1 - 2011/12/1
N2 - This paper reports the centrifuge-based synthesis method of monodisperse hydrogel microspheres possessing multiple compartments under ultra-high centrifugal gravity, and the demonstration of magnetic self-assembly of chain-structures using cellladen Janus-spheres. Our method, enabling gelification of droplets of sodium alginate solution into microparticles without oil, heat or UV, is easy to use, simple and biocompatible. The synthesis procedure takes only a few minutes and can be conducted on a lab-bench, using our Centrifuge-based Droplet Shooting Device (CDSD) and a tabletop centrifuge. The CDSD will be a valuable tool in various fields, such as drug delivery, biotechnology and tissue engineering.
AB - This paper reports the centrifuge-based synthesis method of monodisperse hydrogel microspheres possessing multiple compartments under ultra-high centrifugal gravity, and the demonstration of magnetic self-assembly of chain-structures using cellladen Janus-spheres. Our method, enabling gelification of droplets of sodium alginate solution into microparticles without oil, heat or UV, is easy to use, simple and biocompatible. The synthesis procedure takes only a few minutes and can be conducted on a lab-bench, using our Centrifuge-based Droplet Shooting Device (CDSD) and a tabletop centrifuge. The CDSD will be a valuable tool in various fields, such as drug delivery, biotechnology and tissue engineering.
KW - Anisotropic particle
KW - Centrifuge
KW - Hydrogel
KW - Microfluidics
UR - http://www.scopus.com/inward/record.url?scp=84883808276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883808276&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84883808276
SN - 9781618395955
T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
SP - 12
EP - 14
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Y2 - 2 October 2011 through 6 October 2011
ER -