A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects

Anna Kaisa Niemi; Jukka S. Moilanen; Masashi Tanaka; Antti Hervonen; Mikko Hurme; Terho Lehtimäki; Yasumichi Arai; Nobuyoshi Hirose; Kari Majamaa

doi:10.1038/sj.ejhg.5201308

A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects

Anna Kaisa Niemi, Jukka S. Moilanen, Masashi Tanaka, Antti Hervonen, Mikko Hurme, Terho Lehtimäki, Yasumichi Arai, Nobuyoshi Hirose, Kari Majamaa

Center for Supercentenarian Medical Research

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

Abstract

Mitochondrial DNA (mtDNA) coding region polymorphisms, as well as the 150T polymorphism in the noncoding region, have been associated with longevity. We have studied here the association of 150T with longevity further and assessed differences in this association between various mtDNA haplogroups. We analysed a sample of 321 very old subjects and 489 middle-aged controls from Finland and Japan. 150T was more frequent among the very old than among the controls in both the Finnish and Japanese subjects. Interestingly, the association was not similar in all haplogroups, and a stratified analysis revealed that two additional common polymorphisms, 489C and 10398G, modified the association between 150T and longevity. These findings suggest that longevity is partly determined by epistatic interactions involving these three mtDNA loci.

Original language	English
Pages (from-to)	166-170
Number of pages	5
Journal	European Journal of Human Genetics
Volume	13
Issue number	2
DOIs	https://doi.org/10.1038/sj.ejhg.5201308
Publication status	Published - 2005 Feb

Keywords

Association study
Control region
Epistasis
Haplogroup
Longevity
Mitochondrial DNA
Phylogenetic analysis

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1038/sj.ejhg.5201308

Cite this

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title = "A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects",

abstract = "Mitochondrial DNA (mtDNA) coding region polymorphisms, as well as the 150T polymorphism in the noncoding region, have been associated with longevity. We have studied here the association of 150T with longevity further and assessed differences in this association between various mtDNA haplogroups. We analysed a sample of 321 very old subjects and 489 middle-aged controls from Finland and Japan. 150T was more frequent among the very old than among the controls in both the Finnish and Japanese subjects. Interestingly, the association was not similar in all haplogroups, and a stratified analysis revealed that two additional common polymorphisms, 489C and 10398G, modified the association between 150T and longevity. These findings suggest that longevity is partly determined by epistatic interactions involving these three mtDNA loci.",

keywords = "Association study, Control region, Epistasis, Haplogroup, Longevity, Mitochondrial DNA, Phylogenetic analysis",

author = "Niemi, {Anna Kaisa} and Moilanen, {Jukka S.} and Masashi Tanaka and Antti Hervonen and Mikko Hurme and Terho Lehtim{\"a}ki and Yasumichi Arai and Nobuyoshi Hirose and Kari Majamaa",

note = "Funding Information: We thank Ms Anja Heikkinen and Ms Pirjo Ker{\"a}nen for their expert technical assistance. This study was supported by grants from the Sigrid Juselius Foundation and the Medical Research Council of the Academy of Finland.",

year = "2005",

month = feb,

doi = "10.1038/sj.ejhg.5201308",

language = "English",

volume = "13",

pages = "166--170",

journal = "European Journal of Human Genetics",

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AU - Niemi, Anna Kaisa

AU - Moilanen, Jukka S.

AU - Tanaka, Masashi

AU - Hervonen, Antti

AU - Hurme, Mikko

AU - Lehtimäki, Terho

AU - Arai, Yasumichi

AU - Hirose, Nobuyoshi

AU - Majamaa, Kari

N1 - Funding Information: We thank Ms Anja Heikkinen and Ms Pirjo Keränen for their expert technical assistance. This study was supported by grants from the Sigrid Juselius Foundation and the Medical Research Council of the Academy of Finland.

PY - 2005/2

Y1 - 2005/2

N2 - Mitochondrial DNA (mtDNA) coding region polymorphisms, as well as the 150T polymorphism in the noncoding region, have been associated with longevity. We have studied here the association of 150T with longevity further and assessed differences in this association between various mtDNA haplogroups. We analysed a sample of 321 very old subjects and 489 middle-aged controls from Finland and Japan. 150T was more frequent among the very old than among the controls in both the Finnish and Japanese subjects. Interestingly, the association was not similar in all haplogroups, and a stratified analysis revealed that two additional common polymorphisms, 489C and 10398G, modified the association between 150T and longevity. These findings suggest that longevity is partly determined by epistatic interactions involving these three mtDNA loci.

AB - Mitochondrial DNA (mtDNA) coding region polymorphisms, as well as the 150T polymorphism in the noncoding region, have been associated with longevity. We have studied here the association of 150T with longevity further and assessed differences in this association between various mtDNA haplogroups. We analysed a sample of 321 very old subjects and 489 middle-aged controls from Finland and Japan. 150T was more frequent among the very old than among the controls in both the Finnish and Japanese subjects. Interestingly, the association was not similar in all haplogroups, and a stratified analysis revealed that two additional common polymorphisms, 489C and 10398G, modified the association between 150T and longevity. These findings suggest that longevity is partly determined by epistatic interactions involving these three mtDNA loci.

KW - Association study

KW - Control region

KW - Epistasis

KW - Haplogroup

KW - Longevity

KW - Mitochondrial DNA

KW - Phylogenetic analysis

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JO - European Journal of Human Genetics

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A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects

Abstract

Keywords

ASJC Scopus subject areas

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