A contemporary snapshot of intestinal stem cells and their regulation

Ryo Seishima; Nick Barker

doi:10.1016/j.diff.2019.01.004

A contemporary snapshot of intestinal stem cells and their regulation

Ryo Seishima, Nick Barker

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Intestinal stem cells (ISCs) marked by Lgr5 are located at the bottom of the epithelial crypt compartment. Canonical Wnt signaling, activated by Wnt/Rspo ligands, determines the stem cell identity of Lgr5 + ISCs and is strictly regulated by the ISC niche. Emerging evidence indicates that both epithelial and stromal compartments provide the requisite Wnt/Rspo ligands, confining the ISC niche to the lower crypt regions of the intestine. Recent studies have also shown that the ISC niche can reprogram differentiated cells to replenish lost ISCs following tissue injury, accounting for the epithelial cell plasticity within the crypt compartment. Here we review these recent advances and discuss the role of canonical Wnt signaling in maintaining homeostasis and effecting cell plasticity following tissue injury in the intestine, which could reveal potential novel therapeutic opportunities in the clinic.

Original language	English
Pages (from-to)	3-7
Number of pages	5
Journal	Differentiation
Volume	108
DOIs	https://doi.org/10.1016/j.diff.2019.01.004
Publication status	Published - 2019 Jul 1
Externally published	Yes

Keywords

Intestinal stem cell
Stem cell niche
Wnt signaling

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diff.2019.01.004

Cite this

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title = "A contemporary snapshot of intestinal stem cells and their regulation",

abstract = "Intestinal stem cells (ISCs) marked by Lgr5 are located at the bottom of the epithelial crypt compartment. Canonical Wnt signaling, activated by Wnt/Rspo ligands, determines the stem cell identity of Lgr5 + ISCs and is strictly regulated by the ISC niche. Emerging evidence indicates that both epithelial and stromal compartments provide the requisite Wnt/Rspo ligands, confining the ISC niche to the lower crypt regions of the intestine. Recent studies have also shown that the ISC niche can reprogram differentiated cells to replenish lost ISCs following tissue injury, accounting for the epithelial cell plasticity within the crypt compartment. Here we review these recent advances and discuss the role of canonical Wnt signaling in maintaining homeostasis and effecting cell plasticity following tissue injury in the intestine, which could reveal potential novel therapeutic opportunities in the clinic.",

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AU - Seishima, Ryo

AU - Barker, Nick

PY - 2019/7/1

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AB - Intestinal stem cells (ISCs) marked by Lgr5 are located at the bottom of the epithelial crypt compartment. Canonical Wnt signaling, activated by Wnt/Rspo ligands, determines the stem cell identity of Lgr5 + ISCs and is strictly regulated by the ISC niche. Emerging evidence indicates that both epithelial and stromal compartments provide the requisite Wnt/Rspo ligands, confining the ISC niche to the lower crypt regions of the intestine. Recent studies have also shown that the ISC niche can reprogram differentiated cells to replenish lost ISCs following tissue injury, accounting for the epithelial cell plasticity within the crypt compartment. Here we review these recent advances and discuss the role of canonical Wnt signaling in maintaining homeostasis and effecting cell plasticity following tissue injury in the intestine, which could reveal potential novel therapeutic opportunities in the clinic.

KW - Intestinal stem cell

KW - Stem cell niche

KW - Wnt signaling

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DO - 10.1016/j.diff.2019.01.004

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JF - Differentiation

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A contemporary snapshot of intestinal stem cells and their regulation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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