@article{6ece86c6e64747d4ab54bff1bc01fb32,
title = "A critical mutation in both WT1 alleles is not sufficient to cause Wilms' tumor",
abstract = "The WT1 gene is a tumor suppresser gene for Wilms' tumor (WT). Inactivation of both alleles has been proposed as the cause of WT. We encountered a patient with Denys-Drash syndrome associated with WT whose WT1 gene had a homozygous point mutation not only in WT but also in renal tissue adjacent to the WT and in the germline. These findings indicate that factor(s) other than the loss of WT1 are required for WT to develop.",
keywords = "WT1 gene, Wilms' tumor",
author = "Haruhito Kikuchi and Yoshikiyo Akasaka and Yoshihiro Kurosawa and Hiroshi Yoneyama and Shingo Kato and Hata, {Jun ichi}",
note = "Funding Information: Acknowledgements. We thank Dr. Koichi Shimizu and Takao Kosaka (National Children's Hospital) for providing materials. We also thank Yoshiyuki Hiraishi for his technical assistance. This work is supported by a grant-in-aid for cancer research from the Ministry of Health and Welfare and the Ministry of Education in Japan (03454174), funds provided by the Entrustment of Research Program of the foundation for Promotion of Cancer Research in Japan, a grant from the Vehicle Racing Commemorative Foundation, and Clinical Pathology Research Foundation of Japan.",
year = "1995",
month = feb,
day = "20",
doi = "10.1016/0014-5793(95)00071-G",
language = "English",
volume = "360",
pages = "26--28",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "1",
}