A desmoplastic fibroblastoma that developed in the anterior mediastinum: a case report

Tai Hato, Hiroaki Kashimada, Masatoshi Yamaguchi, Ato Sugiyama, Yoshiaki Inoue, Kohei Aoki, Hiroki Fukuda, Masatoshi Gika, Jun Kikuchi, Takashi Fujino, Takehiko Yamaguchi, Jun ichi Tamaru, Mitsutomo Kohno, Mitsuo Nakayama

Research output: Contribution to journalArticlepeer-review


Background: Desmoplastic fibroblastoma (also known as collagenous fibroma) is a benign, slowly growing soft-tissue tumor. Most desmoplastic fibroblastomas develop in the limbs, neck, or trunk. A mediastinal origin is quite rare. Case presentation: A 32-year-old Asian female was referred to us for the diagnosis and treatment of an anterior mediastinal tumor. The tumor was 80 mm in the largest diameter and was located on the pericardium. No invasion was evident. She underwent resection of the tumor via video-assisted thoracoscopic resection. The tumor was totally encapsulated, and its pedicle was on the pericardium. The resected specimen was very rigid, making it difficult to remove from the intercostal space. Histologically, the tumor was composed of a paucicellular dense collagenous tissue. Mitosis was rarely observed, and cellular atypia was not evident, suggesting that the tumor was benign. We diagnosed the tumor as a desmoplastic fibroblastoma by morphology and immunohistochemistry. Conclusions: Desmoplastic fibroblastoma of the mediastinum is an extremely rare disease. Preoperative diagnosis is difficult. Early surgical resection is suitable for diagnosis and treatment planning.

Original languageEnglish
Article number525
JournalJournal of Medical Case Reports
Issue number1
Publication statusPublished - 2021 Dec
Externally publishedYes


  • Case report
  • Collagenous fibroma
  • Desmoplastic fibroblastoma
  • Mediastinal tumor
  • Video-assisted thoracoscopic surgery

ASJC Scopus subject areas

  • General Medicine


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