TY - JOUR
T1 - A fluorogenic C4N4 probe for azide-based labelling
AU - Noda, Hidetoshi
AU - Asada, Yasuko
AU - Shibasaki, Masakatsu
AU - Kumagai, Naoya
N1 - Funding Information:
This work was financially supported by KAKENHI (17H03025 and 18H04276 in Precisely Designed Catalysts with Customised Scaffolding) from JSPS and MEXT. We are grateful to Dr Ryuichi Sawa, Yumiko Kubota, Dr Kiyoko Iijima, and Yuko Takahashi for assistance with NMR and MS analyses.
Publisher Copyright:
© 2019 The Royal Society of Chemistry.
PY - 2019
Y1 - 2019
N2 - The design, synthesis and photophysical properties of a new fluorogenic probe are described. The structure is based on the recently identified 2,5-diaminopyrimidine (C4N4) fluorophore. The strain-promoted [3 + 2] cycloaddition of the azido-C4N4 probe furnished a triazole that exhibited more than 30-fold enhancement in fluorescence intensity as compared to the azide.
AB - The design, synthesis and photophysical properties of a new fluorogenic probe are described. The structure is based on the recently identified 2,5-diaminopyrimidine (C4N4) fluorophore. The strain-promoted [3 + 2] cycloaddition of the azido-C4N4 probe furnished a triazole that exhibited more than 30-fold enhancement in fluorescence intensity as compared to the azide.
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U2 - 10.1039/c8ob02695e
DO - 10.1039/c8ob02695e
M3 - Article
C2 - 30534778
AN - SCOPUS:85061494659
SN - 1477-0520
VL - 17
SP - 1813
EP - 1816
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 7
ER -