A fluorogenic C4N4 probe for azide-based labelling

Hidetoshi Noda, Yasuko Asada, Masakatsu Shibasaki, Naoya Kumagai

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The design, synthesis and photophysical properties of a new fluorogenic probe are described. The structure is based on the recently identified 2,5-diaminopyrimidine (C4N4) fluorophore. The strain-promoted [3 + 2] cycloaddition of the azido-C4N4 probe furnished a triazole that exhibited more than 30-fold enhancement in fluorescence intensity as compared to the azide.

Original languageEnglish
Pages (from-to)1813-1816
Number of pages4
JournalOrganic and Biomolecular Chemistry
Issue number7
Publication statusPublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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