A Glucan Having Reticuloendothelial System-Potentiating and Anti-complementary Activities from the Tuber of Pinellia ternata

Masashi Tomoda; RyōKo Gonda; Naoko Ōhara; Noriko Shimizu; Chiho Shishido; Yuka Fujiki

doi:10.1248/bpb.17.859

A Glucan Having Reticuloendothelial System-Potentiating and Anti-complementary Activities from the Tuber of Pinellia ternata

Masashi Tomoda, RyōKo Gonda, Naoko Ōhara, Noriko Shimizu, Chiho Shishido, Yuka Fujiki

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A glucan, called pinellian G, was isolated from the tuber of Pinellia ternata Breit. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 1.5 x 10⁴. It is composed solely of D-glucose, in addition to a few O-acetyl groups. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it is a branched glucan mainly composed of α-l,4-linked D-glucopyranose residues with partially α-l,3-linked units and 4,6-branching points. The glucan showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as pronounced anti-complementary activity.

Original language	English
Pages (from-to)	859-861
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	17
Issue number	6
DOIs	https://doi.org/10.1248/bpb.17.859
Publication status	Published - 1994

Keywords

Pinellia ternata
glucan
immunological activity
pinellian G
polysaccharide structure

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Access to Document

10.1248/bpb.17.859

Cite this

@article{b1f710da357641c9a24aabcf58671fd8,

title = "A Glucan Having Reticuloendothelial System-Potentiating and Anti-complementary Activities from the Tuber of Pinellia ternata",

abstract = "A glucan, called pinellian G, was isolated from the tuber of Pinellia ternata Breit. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 1.5 x 104. It is composed solely of D-glucose, in addition to a few O-acetyl groups. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it is a branched glucan mainly composed of α-l,4-linked D-glucopyranose residues with partially α-l,3-linked units and 4,6-branching points. The glucan showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as pronounced anti-complementary activity.",

keywords = "Pinellia ternata, glucan, immunological activity, pinellian G, polysaccharide structure",

author = "Masashi Tomoda and RyōKo Gonda and Naoko Ōhara and Noriko Shimizu and Chiho Shishido and Yuka Fujiki",

year = "1994",

doi = "10.1248/bpb.17.859",

language = "English",

volume = "17",

pages = "859--861",

journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

publisher = "Pharmaceutical Society of Japan",

number = "6",

}

TY - JOUR

T1 - A Glucan Having Reticuloendothelial System-Potentiating and Anti-complementary Activities from the Tuber of Pinellia ternata

AU - Tomoda, Masashi

AU - Gonda, RyōKo

AU - Ōhara, Naoko

AU - Shimizu, Noriko

AU - Shishido, Chiho

AU - Fujiki, Yuka

PY - 1994

Y1 - 1994

N2 - A glucan, called pinellian G, was isolated from the tuber of Pinellia ternata Breit. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 1.5 x 104. It is composed solely of D-glucose, in addition to a few O-acetyl groups. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it is a branched glucan mainly composed of α-l,4-linked D-glucopyranose residues with partially α-l,3-linked units and 4,6-branching points. The glucan showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as pronounced anti-complementary activity.

AB - A glucan, called pinellian G, was isolated from the tuber of Pinellia ternata Breit. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 1.5 x 104. It is composed solely of D-glucose, in addition to a few O-acetyl groups. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it is a branched glucan mainly composed of α-l,4-linked D-glucopyranose residues with partially α-l,3-linked units and 4,6-branching points. The glucan showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as pronounced anti-complementary activity.

KW - Pinellia ternata

KW - glucan

KW - immunological activity

KW - pinellian G

KW - polysaccharide structure

UR - http://www.scopus.com/inward/record.url?scp=0028037588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028037588&partnerID=8YFLogxK

U2 - 10.1248/bpb.17.859

DO - 10.1248/bpb.17.859

M3 - Article

C2 - 7951156

AN - SCOPUS:0028037588

SN - 0918-6158

VL - 17

SP - 859

EP - 861

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 6

ER -

A Glucan Having Reticuloendothelial System-Potentiating and Anti-complementary Activities from the Tuber of Pinellia ternata

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this