A GluD Coming-Of-Age Story

Michisuke Yuzaki, A. Radu Aricescu

Research output: Contribution to journalReview articlepeer-review

58 Citations (Scopus)


The GluD1 and GluD2 receptors form the GluD ionotropic glutamate receptor (iGluR) subfamily. Without known endogenous ligands, they have long been referred to as ‘orphan’ and remained enigmatic functionally. Recent progress has, however, radically changed this view. Both GluD receptors are expressed in wider brain regions than originally thought. Human genetic studies and analyses of knockout mice have revealed their involvement in multiple neurodevelopmental and psychiatric disorders. The discovery of endogenous ligands, together with structural investigations, has opened the way towards a mechanistic understanding of GluD signaling at central nervous system synapses. These studies have also prompted the hypothesis that all iGluRs, and potentially other neurotransmitter receptors, rely on the cooperative binding of extracellular small-molecule and protein ligands for physiological signaling.

Original languageEnglish
Pages (from-to)138-150
Number of pages13
JournalTrends in Neurosciences
Issue number3
Publication statusPublished - 2017 Mar 1

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'A GluD Coming-Of-Age Story'. Together they form a unique fingerprint.

Cite this