A Japanese nationwide survey on the cryopreservation of embryos, oocytes and ovarian tissue for cancer patients

Yuko Sanada, Miyuki Harada, Chisato Kunitomi, Mayuko Kanatani, Gentaro Izumi, Tetsuya Hirata, Tomoyuki Fujii, Nao Suzuki, Ken ichirou Morishige, Daisuke Aoki, Minoru Irahara, Koichiro Tsugawa, Mitsune Tanimoto, Hiroyuki Nishiyama, Hajime Hosoi, Kazuhiko Sugiyama, Akira Kawai, Yutaka Osuga

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Aim: The survival rates of cancer patients have greatly improved owing to the advances in oncology. The preservation of fertility in cancer patients is an important task. To determine the reality of cryopreservation of embryos, oocytes and ovarian tissue in cancer patients, large-scale survey analysis was performed in Japan. Methods: We sent 613 Japan Society of Obstetrics and Gynecology-certified assisted reproductive technology institutions a questionnaire about their experience of performing cryopreservation for cancer patients between January 2011 and December 2015. Subsequently, the institutions that conducted cryopreservation for cancer patients were sent a second questionnaire. Results: We received replies from 481 (78.5%) institutions. Among them, 126 (26.2%) conducted cryopreservation for cancer patients. These 126 institutions were sent a second questionnaire. Of these, 108 (85.7%) institutions responded. At the 108 institutions, 1085 embryo or oocyte cryopreservation procedures and 122 ovarian tissue cryopreservation procedures were conducted for cancer patients. Cryopreservation was mainly performed for breast cancer patients (~70%), followed by patients with hematological malignancy. A total of 361 and 19 embryo transfer cycles were performed for patients whose embryos and oocytes were cryopreserved, respectively, and 42 and seven institutions reported pregnancy outcomes after embryo transfer in patients that underwent embryo and oocyte cryopreservation, respectively. However, pregnancy was not observed in the seven cases that underwent ovarian tissue transfer. Conclusion: Indications, age limits and ovarian stimulation protocols for cryopreservation widely varied between the institutions. A national registration system for oncofertility must be established to evaluate the safety and efficacy of the current system.

Original languageEnglish
Pages (from-to)2021-2028
Number of pages8
JournalJournal of Obstetrics and Gynaecology Research
Issue number10
Publication statusPublished - 2019 Oct 1


  • assisted reproductive technology
  • breast cancer
  • controlled ovarian stimulation
  • cryopreservation
  • oncofertility

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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