A kaurene-type novel phytotoxic substance in Wedelia chinensis

Krishna Rany Das; Arihiro Iwasaki; Kiyotake Suenaga; Hisashi Kato-Noguchi

doi:10.1016/j.tetlet.2020.151600

A kaurene-type novel phytotoxic substance in Wedelia chinensis

Krishna Rany Das, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Wedelia chinensis has been widely used as a traditional medicine and several bioactive compounds have been isolated. We investigated phytotoxic property and phytotoxic substances in the species. An aqueous methanol extract of W. chinensis inhibited the growth of roots and shoots of cress. The extracts were then purified by several chromatographic runs with monitoring the inhibitory activity and a phytotoxic substance was isolated. The substance was determined by spectral data to be a novel kaurene-type compound, wedelienone. Wedelienone inhibited the growth of cress and timothy (Phleum pratense L) at concentrations greater than 10–30 μM. These results suggest that wedelienone may contribute to the phytotoxic effects caused by the extracts.

Original language	English
Article number	151600
Journal	Tetrahedron Letters
Volume	61
Issue number	11
DOIs	https://doi.org/10.1016/j.tetlet.2020.151600
Publication status	Published - 2020 Mar 12

Keywords

Bioactive compound
Growth inhibitor
Kaurene
Phytotoxicity
Wedelia chinensis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2020.151600

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title = "A kaurene-type novel phytotoxic substance in Wedelia chinensis",

abstract = "Wedelia chinensis has been widely used as a traditional medicine and several bioactive compounds have been isolated. We investigated phytotoxic property and phytotoxic substances in the species. An aqueous methanol extract of W. chinensis inhibited the growth of roots and shoots of cress. The extracts were then purified by several chromatographic runs with monitoring the inhibitory activity and a phytotoxic substance was isolated. The substance was determined by spectral data to be a novel kaurene-type compound, wedelienone. Wedelienone inhibited the growth of cress and timothy (Phleum pratense L) at concentrations greater than 10–30 μM. These results suggest that wedelienone may contribute to the phytotoxic effects caused by the extracts.",

keywords = "Bioactive compound, Growth inhibitor, Kaurene, Phytotoxicity, Wedelia chinensis",

author = "{Rany Das}, Krishna and Arihiro Iwasaki and Kiyotake Suenaga and Hisashi Kato-Noguchi",

note = "Funding Information: This work was partly supported by Asia Joint Research Promotion Fund of Kagawa University Research Promotion Program 2019. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

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doi = "10.1016/j.tetlet.2020.151600",

language = "English",

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AU - Rany Das, Krishna

AU - Iwasaki, Arihiro

AU - Suenaga, Kiyotake

AU - Kato-Noguchi, Hisashi

PY - 2020/3/12

Y1 - 2020/3/12

N2 - Wedelia chinensis has been widely used as a traditional medicine and several bioactive compounds have been isolated. We investigated phytotoxic property and phytotoxic substances in the species. An aqueous methanol extract of W. chinensis inhibited the growth of roots and shoots of cress. The extracts were then purified by several chromatographic runs with monitoring the inhibitory activity and a phytotoxic substance was isolated. The substance was determined by spectral data to be a novel kaurene-type compound, wedelienone. Wedelienone inhibited the growth of cress and timothy (Phleum pratense L) at concentrations greater than 10–30 μM. These results suggest that wedelienone may contribute to the phytotoxic effects caused by the extracts.

AB - Wedelia chinensis has been widely used as a traditional medicine and several bioactive compounds have been isolated. We investigated phytotoxic property and phytotoxic substances in the species. An aqueous methanol extract of W. chinensis inhibited the growth of roots and shoots of cress. The extracts were then purified by several chromatographic runs with monitoring the inhibitory activity and a phytotoxic substance was isolated. The substance was determined by spectral data to be a novel kaurene-type compound, wedelienone. Wedelienone inhibited the growth of cress and timothy (Phleum pratense L) at concentrations greater than 10–30 μM. These results suggest that wedelienone may contribute to the phytotoxic effects caused by the extracts.

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KW - Kaurene

KW - Phytotoxicity

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A kaurene-type novel phytotoxic substance in Wedelia chinensis

Abstract

Keywords

ASJC Scopus subject areas

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