A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice

Toshiharu Furukawa; Tetsuro Kubota; Masahiko Watanabe; Tsong Hong Kuo; Hideki Nishibori; Suguru Kase; Yoshirou Saikawa; Hirokazu Tanino; Tatsuo Teramoto; Kyuya Ishibiki; Masaki Kitajima

doi:10.1007/BF00309500

A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice

Toshiharu Furukawa, Tetsuro Kubota, Masahiko Watanabe, Tsong Hong Kuo, Hideki Nishibori, Suguru Kase, Yoshirou Saikawa, Hirokazu Tanino, Tatsuo Teramoto, Kyuya Ishibiki, Masaki Kitajima

Law School

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

COL-2-JCK, a human colon cancer xenograft line able to be transplanted into nude mice, was implanted in the subserosal layer of the cecum, either as cancer tissue or as a single cell suspension. When cancer tissue was used for the cecal implantation, 100% extensive local tumor growth and a high incidence of metastases to the regional lymph nodes, peritoneum, liver, and lung was observed. In contrast, when the cell suspension of this line was injected into the cecal wall, no metastases were observed, with significantly reduced local tumor growth. The use of cancer tissue maintaining the original cancer tissue structure is therefore considered imperative for allowing full expression of the biological characteristics of cancer cells. This nude mouse model using the cecal implantation of cancer tissue should thus prompt further study on the biology of human colon cancer.

Original language	English
Pages (from-to)	420-423
Number of pages	4
Journal	Surgery today
Volume	23
Issue number	5
DOIs	https://doi.org/10.1007/BF00309500
Publication status	Published - 1993 May 1

Keywords

human colon cancer
metastases
nude mouse

ASJC Scopus subject areas

Surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF00309500

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title = "A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice",

abstract = "COL-2-JCK, a human colon cancer xenograft line able to be transplanted into nude mice, was implanted in the subserosal layer of the cecum, either as cancer tissue or as a single cell suspension. When cancer tissue was used for the cecal implantation, 100% extensive local tumor growth and a high incidence of metastases to the regional lymph nodes, peritoneum, liver, and lung was observed. In contrast, when the cell suspension of this line was injected into the cecal wall, no metastases were observed, with significantly reduced local tumor growth. The use of cancer tissue maintaining the original cancer tissue structure is therefore considered imperative for allowing full expression of the biological characteristics of cancer cells. This nude mouse model using the cecal implantation of cancer tissue should thus prompt further study on the biology of human colon cancer.",

keywords = "human colon cancer, metastases, nude mouse",

author = "Toshiharu Furukawa and Tetsuro Kubota and Masahiko Watanabe and Kuo, {Tsong Hong} and Hideki Nishibori and Suguru Kase and Yoshirou Saikawa and Hirokazu Tanino and Tatsuo Teramoto and Kyuya Ishibiki and Masaki Kitajima",

year = "1993",

month = may,

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doi = "10.1007/BF00309500",

language = "English",

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journal = "Surgery today",

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T1 - A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice

AU - Furukawa, Toshiharu

AU - Kubota, Tetsuro

AU - Watanabe, Masahiko

AU - Kuo, Tsong Hong

AU - Nishibori, Hideki

AU - Kase, Suguru

AU - Saikawa, Yoshirou

AU - Tanino, Hirokazu

AU - Teramoto, Tatsuo

AU - Ishibiki, Kyuya

AU - Kitajima, Masaki

PY - 1993/5/1

Y1 - 1993/5/1

N2 - COL-2-JCK, a human colon cancer xenograft line able to be transplanted into nude mice, was implanted in the subserosal layer of the cecum, either as cancer tissue or as a single cell suspension. When cancer tissue was used for the cecal implantation, 100% extensive local tumor growth and a high incidence of metastases to the regional lymph nodes, peritoneum, liver, and lung was observed. In contrast, when the cell suspension of this line was injected into the cecal wall, no metastases were observed, with significantly reduced local tumor growth. The use of cancer tissue maintaining the original cancer tissue structure is therefore considered imperative for allowing full expression of the biological characteristics of cancer cells. This nude mouse model using the cecal implantation of cancer tissue should thus prompt further study on the biology of human colon cancer.

AB - COL-2-JCK, a human colon cancer xenograft line able to be transplanted into nude mice, was implanted in the subserosal layer of the cecum, either as cancer tissue or as a single cell suspension. When cancer tissue was used for the cecal implantation, 100% extensive local tumor growth and a high incidence of metastases to the regional lymph nodes, peritoneum, liver, and lung was observed. In contrast, when the cell suspension of this line was injected into the cecal wall, no metastases were observed, with significantly reduced local tumor growth. The use of cancer tissue maintaining the original cancer tissue structure is therefore considered imperative for allowing full expression of the biological characteristics of cancer cells. This nude mouse model using the cecal implantation of cancer tissue should thus prompt further study on the biology of human colon cancer.

KW - human colon cancer

KW - metastases

KW - nude mouse

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JO - Surgery today

JF - Surgery today

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ER -

A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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