TY - JOUR
T1 - A new perspective on the mechanism of asymmetric amplification
AU - Asakura, Kouichi
AU - Yamamoto, Tetsuya
AU - Inoue, Sawako
AU - Osanai, Shuichi
AU - Kondepudi, Dilip K.
AU - Yamaguchi, Tomohiko
N1 - Funding Information:
We thank Grants-in-Aid for Scientific Research (C) from Japan Society for Promotion of Science (4830) and for the 21st Century COE program ‘Keio Life Conjugate Chemistry’ from the Ministry of Education, Culture, Sports, Science and Technology, Japan for supporting this work.
PY - 2005/5/2
Y1 - 2005/5/2
N2 - A mechanism of asymmetric amplification, i.e., chemical reaction in which enantiomeric excess, ee, of a product is higher than that of chiral auxiliary for catalyst, was investigated. The reaction rate and the ee of the product differed significantly when the order of reagent addition was changed. A kinetic model formulated to explain this phenomenon predicted that the ee of the product should vary during the reaction. Our experimental investigation indeed found the variation of ee predicted by this theoretical model. There has been no previous report observing such a variation in ee during asymmetric amplification and a different ee produced by changing the order of reagent addition.
AB - A mechanism of asymmetric amplification, i.e., chemical reaction in which enantiomeric excess, ee, of a product is higher than that of chiral auxiliary for catalyst, was investigated. The reaction rate and the ee of the product differed significantly when the order of reagent addition was changed. A kinetic model formulated to explain this phenomenon predicted that the ee of the product should vary during the reaction. Our experimental investigation indeed found the variation of ee predicted by this theoretical model. There has been no previous report observing such a variation in ee during asymmetric amplification and a different ee produced by changing the order of reagent addition.
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U2 - 10.1016/j.cplett.2005.03.009
DO - 10.1016/j.cplett.2005.03.009
M3 - Article
AN - SCOPUS:16644385480
SN - 0009-2614
VL - 406
SP - 312
EP - 317
JO - Chemical Physics Letters
JF - Chemical Physics Letters
IS - 4-6
ER -