A novel gene delivery system using EGF receptor-mediated endocytosis

Jiabing Chen; Shinobu Gamou; Atsushi Takayanagi; Nobuyoshi Shimizu

doi:10.1016/0014-5793(94)80357-9

A novel gene delivery system using EGF receptor-mediated endocytosis

Jiabing Chen, Shinobu Gamou, Atsushi Takayanagi, Nobuyoshi Shimizu

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

Abstract

A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.

Original language	English
Pages (from-to)	167-169
Number of pages	3
Journal	FEBS Letters
Volume	338
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(94)80357-9
Publication status	Published - 1994 Jan 31
Externally published	Yes

Keywords

EGF receptor
Endocytosis
Gene therapy
Monoclonal antibody

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(94)80357-9

Cite this

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title = "A novel gene delivery system using EGF receptor-mediated endocytosis",

abstract = "A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.",

keywords = "EGF receptor, Endocytosis, Gene therapy, Monoclonal antibody",

author = "Jiabing Chen and Shinobu Gamou and Atsushi Takayanagi and Nobuyoshi Shimizu",

year = "1994",

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AU - Gamou, Shinobu

AU - Takayanagi, Atsushi

AU - Shimizu, Nobuyoshi

PY - 1994/1/31

Y1 - 1994/1/31

N2 - A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.

AB - A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.

KW - EGF receptor

KW - Endocytosis

KW - Gene therapy

KW - Monoclonal antibody

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A novel gene delivery system using EGF receptor-mediated endocytosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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