A paradigm shift in rheumatoid arthritis over the past decade

Yuko Kaneko, Tsutomu Takeuchi

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


Recent advances have improved our understanding of the pathogenesis of rheumatoid arthritis (RA), and the development of new therapeutics, including biological agents, have thus made it possible to strive for remission as a primary goal. Biological agents targeting a specific molecule have powerful functional capabilities, and the introduction of biological therapies has brought about revolutionary progress in RA management, culminating in a paradigm shift. There is clear evidence that a delay in treatment initiation and poor control of disease activity are associated with joint damage progression, so treatment should be started immediately after the diagnosis of RA and adapted according to disease activity as assessed by validated composite measures. In this review, we will summarize the changes in the classification and remission criteria and describe the clinical efficacies of biological agents in RA. We also discuss new promising therapies and propose future perspectives in the rheumatology field.

Original languageEnglish
Pages (from-to)1895-1903
Number of pages9
JournalInternal Medicine
Issue number17
Publication statusPublished - 2014


  • Biological agent
  • Paradigm shift
  • Rheumatoid arthritis
  • Treat-to-target

ASJC Scopus subject areas

  • Internal Medicine


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