A pharmacokinetic analysis program (multi) for microcomputer

Kiyoshi Yamaoka, Yusuke Tanigawara, Terumichi Nakagawa, Toyozo Uno

Research output: Contribution to journalArticlepeer-review

2690 Citations (Scopus)


A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions or MULTI are demonstrated for time courses of ampicillin and oxacillin in man.

Original languageEnglish
Pages (from-to)879-885
Number of pages7
JournalJournal of Pharmacobio-Dynamics
Issue number11
Publication statusPublished - 1981
Externally publishedYes


  • AIC
  • SALS
  • curve fitting
  • least squares
  • microcomputer
  • pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology


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