A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

Yoshihiko Yasohara; Kenji Miyamoto; Noriyuku Kizaki; Junzo Hasegawa; Takehisa Ohashi

doi:10.1016/S0040-4039(01)00425-7

A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

Yoshihiko Yasohara, Kenji Miyamoto, Noriyuku Kizaki, Junzo Hasegawa, Takehisa Ohashi

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.

Original language	English
Pages (from-to)	3331-3333
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	19
DOIs	https://doi.org/10.1016/S0040-4039(01)00425-7
Publication status	Published - 2001 May 7
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)00425-7

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title = "A practical chemoenzymatic synthesis of a key intermediate of antifungal agents",

abstract = "A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.",

author = "Yoshihiko Yasohara and Kenji Miyamoto and Noriyuku Kizaki and Junzo Hasegawa and Takehisa Ohashi",

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AU - Yasohara, Yoshihiko

AU - Miyamoto, Kenji

AU - Kizaki, Noriyuku

AU - Hasegawa, Junzo

AU - Ohashi, Takehisa

PY - 2001/5/7

Y1 - 2001/5/7

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U2 - 10.1016/S0040-4039(01)00425-7

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EP - 3333

JO - Tetrahedron Letters

JF - Tetrahedron Letters

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A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

Abstract

ASJC Scopus subject areas

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