A reduction of HbAs1c after 3 months predicts 2-year responsiveness to sitagliptin treatment

Takeshi Nishimura, Shu Meguro, Risa Sekioka, Karin Tanaka, Yoshifumi Saisho, Junichiro Irie, Masami Tanaka, Toshihide Kawai, Hiroshi Itoh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Objective This retrospective study evaluated the long-term efficacy of sitagliptin and the factors contributing to its glucose-lowering effect. Methods Six hundred and sixteen dipeptidyl peptidase-4 inhibitor-naïve outpatients with type 2 diabetes who began sitagliptin treatment between December 1, 2009 and December 31, 2011 were included in this study. The inclusion criteria were that the patient had regularly visited our hospital for a period of <700 days from the initiation of sitagliptin treatment and the measurement of hemoglobin A1c (HbA1c) had been performed at 0, 3, 6, 12, 18, and 24 months after the initiation of treatment. From the population of 616 patients, 447 and 169 had received sitagliptin for [1]700 and <700 days, respectively. The primary endpoint was ΔHbA1c at 24 months. The factors associated with the hypoglycemic effect of sitagliptin were also investigated. Results Sitagliptin treatment significantly decreased the level of HbA1c, and the hypoglycemic effect was sustained for at least 2 years. The baseline HbA1c level, duration of diabetes, Δbody weight value, and ΔHbA1c value at 3 months were independently associated with the hypoglycemic effect of sitagliptin. Conclusion Sitagliptin has a long-term hypoglycemic effect in type 2 diabetes patients. A patient’s ΔHbA1c at 3 months may be a predictor of their ΔHbA1c at 24 months.

Original languageEnglish
Pages (from-to)2981-2989
Number of pages9
JournalInternal Medicine
Issue number23
Publication statusPublished - 2015 Dec 1


  • Diabetes
  • Dipeptidyl peptidase-4 inhibitor
  • Glycemic control
  • HbA1c
  • Hemoglobin
  • Sitagliptin

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'A reduction of HbAs1c after 3 months predicts 2-year responsiveness to sitagliptin treatment'. Together they form a unique fingerprint.

Cite this