A successful antimicrobial therapeutic strategy for the discitis caused by Aggregatibacter actinomycetemcomitans under unknown drug susceptibility: A case report

Shunsuke Uno; Yosuke Horiuchi; Takae Uchida; Akiko Yonaha; Takanori Miyata; Eiko Nagano; Takao Kodama; Naoki Hasegawa

doi:10.1016/j.jiac.2018.03.013

A successful antimicrobial therapeutic strategy for the discitis caused by Aggregatibacter actinomycetemcomitans under unknown drug susceptibility: A case report

Shunsuke Uno, Yosuke Horiuchi, Takae Uchida, Akiko Yonaha, Takanori Miyata, Eiko Nagano, Takao Kodama, Naoki Hasegawa

Department of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Aggregatibacter actinomycetemcomitans is well-known as the pathogen of gingivitis or periodontitis, and discitis or vertebral osteomyelitis cases caused by this organism have rarely been reported. Ampicillin or amoxicillin has been used in the previously reported discitis cases; however, no cases have been reported that is treated with levofloxacin. We report the first published case we chose levofloxacin to treat. We failed to perform the susceptibility testing because of the poor growth and fastidious nature of the organism, and the result of susceptibility of amoxicillin was unclear. Levofloxacin, which A. actinomycetemcomitans is usually susceptible to, can be an effective alternative oral antimicrobial agent in such cases.

Original language	English
Pages (from-to)	849-851
Number of pages	3
Journal	Journal of Infection and Chemotherapy
Volume	24
Issue number	10
DOIs	https://doi.org/10.1016/j.jiac.2018.03.013
Publication status	Published - 2018 Oct

Keywords

Aggregatibacter actinomycetemcomitans
Discitis
Levofloxacin
Quinolone

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jiac.2018.03.013

Cite this

Uno, S, Horiuchi, Y, Uchida, T, Yonaha, A, Miyata, T, Nagano, E, Kodama, T & Hasegawa, N 2018, 'A successful antimicrobial therapeutic strategy for the discitis caused by Aggregatibacter actinomycetemcomitans under unknown drug susceptibility: A case report', Journal of Infection and Chemotherapy, vol. 24, no. 10, pp. 849-851. https://doi.org/10.1016/j.jiac.2018.03.013

@article{729aee7af83b48c0924490670d6bde6b,

title = "A successful antimicrobial therapeutic strategy for the discitis caused by Aggregatibacter actinomycetemcomitans under unknown drug susceptibility: A case report",

abstract = "Aggregatibacter actinomycetemcomitans is well-known as the pathogen of gingivitis or periodontitis, and discitis or vertebral osteomyelitis cases caused by this organism have rarely been reported. Ampicillin or amoxicillin has been used in the previously reported discitis cases; however, no cases have been reported that is treated with levofloxacin. We report the first published case we chose levofloxacin to treat. We failed to perform the susceptibility testing because of the poor growth and fastidious nature of the organism, and the result of susceptibility of amoxicillin was unclear. Levofloxacin, which A. actinomycetemcomitans is usually susceptible to, can be an effective alternative oral antimicrobial agent in such cases.",

keywords = "Aggregatibacter actinomycetemcomitans, Discitis, Levofloxacin, Quinolone",

author = "Shunsuke Uno and Yosuke Horiuchi and Takae Uchida and Akiko Yonaha and Takanori Miyata and Eiko Nagano and Takao Kodama and Naoki Hasegawa",

note = "Publisher Copyright: {\textcopyright} 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases",

year = "2018",

month = oct,

doi = "10.1016/j.jiac.2018.03.013",

language = "English",

volume = "24",

pages = "849--851",

journal = "Journal of Infection and Chemotherapy",

issn = "1341-321X",

publisher = "Elsevier BV",

number = "10",

}

TY - JOUR

T1 - A successful antimicrobial therapeutic strategy for the discitis caused by Aggregatibacter actinomycetemcomitans under unknown drug susceptibility

T2 - A case report

AU - Uno, Shunsuke

AU - Horiuchi, Yosuke

AU - Uchida, Takae

AU - Yonaha, Akiko

AU - Miyata, Takanori

AU - Nagano, Eiko

AU - Kodama, Takao

AU - Hasegawa, Naoki

PY - 2018/10

Y1 - 2018/10

N2 - Aggregatibacter actinomycetemcomitans is well-known as the pathogen of gingivitis or periodontitis, and discitis or vertebral osteomyelitis cases caused by this organism have rarely been reported. Ampicillin or amoxicillin has been used in the previously reported discitis cases; however, no cases have been reported that is treated with levofloxacin. We report the first published case we chose levofloxacin to treat. We failed to perform the susceptibility testing because of the poor growth and fastidious nature of the organism, and the result of susceptibility of amoxicillin was unclear. Levofloxacin, which A. actinomycetemcomitans is usually susceptible to, can be an effective alternative oral antimicrobial agent in such cases.

AB - Aggregatibacter actinomycetemcomitans is well-known as the pathogen of gingivitis or periodontitis, and discitis or vertebral osteomyelitis cases caused by this organism have rarely been reported. Ampicillin or amoxicillin has been used in the previously reported discitis cases; however, no cases have been reported that is treated with levofloxacin. We report the first published case we chose levofloxacin to treat. We failed to perform the susceptibility testing because of the poor growth and fastidious nature of the organism, and the result of susceptibility of amoxicillin was unclear. Levofloxacin, which A. actinomycetemcomitans is usually susceptible to, can be an effective alternative oral antimicrobial agent in such cases.

KW - Aggregatibacter actinomycetemcomitans

KW - Discitis

KW - Levofloxacin

KW - Quinolone

UR - http://www.scopus.com/inward/record.url?scp=85045831825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045831825&partnerID=8YFLogxK

U2 - 10.1016/j.jiac.2018.03.013

DO - 10.1016/j.jiac.2018.03.013

M3 - Article

C2 - 29685853

AN - SCOPUS:85045831825

SN - 1341-321X

VL - 24

SP - 849

EP - 851

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

IS - 10

ER -

A successful antimicrobial therapeutic strategy for the discitis caused by Aggregatibacter actinomycetemcomitans under unknown drug susceptibility: A case report

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this