A temporo-spatial regulation of sema3c is essential for interaction of progenitor cells during cardiac outflow tract development

Kazuki Kodo; Shinsuke Shibata; Sachiko Miyagawa-Tomita; Sang Ging Ong; Hiroshi Takahashi; Tsutomu Kume; Hideyuki Okano; Rumiko Matsuoka; Hiroyuki Yamagishi

doi:10.1007/978-981-15-1185-1_58

A temporo-spatial regulation of sema3c is essential for interaction of progenitor cells during cardiac outflow tract development

Kazuki Kodo, Shinsuke Shibata, Sachiko Miyagawa-Tomita, Sang Ging Ong, Hiroshi Takahashi, Tsutomu Kume, Hideyuki Okano, Rumiko Matsuoka, Hiroyuki Yamagishi

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The two cardiac progenitor cell lineages, cardiac neural crest cells (cNCCs) and the second heart field (SHF), play key roles in the development of the cardiac outflow tract (OFT). Both cardiac progenitor cells interact with each other and contribute to OFT formation cooperatively. The neurovascular guiding molecule, semaphorin 3c (Sema3c), is thought to serve as a key attractant for the migration of cNCCs. A previous study reported that Tbx1 null mice showed a significant reduction in Sema3c expression in the OFT region [1]. However, the regulatory effect of Tbx1 on Sema3c was unclear. Here, we show that Sema3c plays key roles in cNCCs-SHF interactions through the regulation by Tbx1 and other molecules during OFT development [2].

Original language	English
Title of host publication	Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
Publisher	Springer Singapore
Pages	377-379
Number of pages	3
ISBN (Electronic)	9789811511851
ISBN (Print)	9789811511844
DOIs	https://doi.org/10.1007/978-981-15-1185-1_58
Publication status	Published - 2020 Jan 1

Keywords

Cardiac neural crest cell
Congenital heart disease
Second heart field
TBX1

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-981-15-1185-1_58

Cite this

Kodo, K., Shibata, S., Miyagawa-Tomita, S., Ong, S. G., Takahashi, H., Kume, T., Okano, H., Matsuoka, R., & Yamagishi, H. (2020). A temporo-spatial regulation of sema3c is essential for interaction of progenitor cells during cardiac outflow tract development. In Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension (pp. 377-379). Springer Singapore. https://doi.org/10.1007/978-981-15-1185-1_58

A temporo-spatial regulation of sema3c is essential for interaction of progenitor cells during cardiac outflow tract development. / Kodo, Kazuki; Shibata, Shinsuke; Miyagawa-Tomita, Sachiko et al.
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension. Springer Singapore, 2020. p. 377-379.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Kodo, K, Shibata, S, Miyagawa-Tomita, S, Ong, SG, Takahashi, H, Kume, T, Okano, H, Matsuoka, R & Yamagishi, H 2020, A temporo-spatial regulation of sema3c is essential for interaction of progenitor cells during cardiac outflow tract development. in Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension. Springer Singapore, pp. 377-379. https://doi.org/10.1007/978-981-15-1185-1_58

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abstract = "The two cardiac progenitor cell lineages, cardiac neural crest cells (cNCCs) and the second heart field (SHF), play key roles in the development of the cardiac outflow tract (OFT). Both cardiac progenitor cells interact with each other and contribute to OFT formation cooperatively. The neurovascular guiding molecule, semaphorin 3c (Sema3c), is thought to serve as a key attractant for the migration of cNCCs. A previous study reported that Tbx1 null mice showed a significant reduction in Sema3c expression in the OFT region [1]. However, the regulatory effect of Tbx1 on Sema3c was unclear. Here, we show that Sema3c plays key roles in cNCCs-SHF interactions through the regulation by Tbx1 and other molecules during OFT development [2].",

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author = "Kazuki Kodo and Shinsuke Shibata and Sachiko Miyagawa-Tomita and Ong, {Sang Ging} and Hiroshi Takahashi and Tsutomu Kume and Hideyuki Okano and Rumiko Matsuoka and Hiroyuki Yamagishi",

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AU - Ong, Sang Ging

AU - Takahashi, Hiroshi

AU - Kume, Tsutomu

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AU - Matsuoka, Rumiko

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AB - The two cardiac progenitor cell lineages, cardiac neural crest cells (cNCCs) and the second heart field (SHF), play key roles in the development of the cardiac outflow tract (OFT). Both cardiac progenitor cells interact with each other and contribute to OFT formation cooperatively. The neurovascular guiding molecule, semaphorin 3c (Sema3c), is thought to serve as a key attractant for the migration of cNCCs. A previous study reported that Tbx1 null mice showed a significant reduction in Sema3c expression in the OFT region [1]. However, the regulatory effect of Tbx1 on Sema3c was unclear. Here, we show that Sema3c plays key roles in cNCCs-SHF interactions through the regulation by Tbx1 and other molecules during OFT development [2].

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A temporo-spatial regulation of sema3c is essential for interaction of progenitor cells during cardiac outflow tract development

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Keywords

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