A thirst for enantioselectivity in catalytic addition of alkylnitriles

Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


This Highlight Review sheds light on a neglected aspect of alkylnitriles in synthetic organic chemistry. The chemical inertness and highly polar nature of alkylnitriles have particular utility as a reaction solvent. Alkylnitriles, however, also serve as potential building blocks for constructing carbon frameworks of interest. Two decades of exploratory studies of this elusive reaction revealed competent catalytic systems that allow for catalytic and enantioselective coupling of alkylnitriles with electrophiles.

Original languageEnglish
Pages (from-to)1322-1327
Number of pages6
JournalChemistry Letters
Issue number11
Publication statusPublished - 2019
Externally publishedYes


  • Acetonitrile
  • Asymmetric catalysis
  • C-C bond formation

ASJC Scopus subject areas

  • Chemistry(all)


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