TY - JOUR
T1 - A thyroid adenoma in a pubertal male with thyroxine-binding globulin deficiency
AU - Kim, Heeyung
AU - Naiki, Yasuhiro
AU - Iwahashi-Odano, Megumi
AU - Narumi, Satoshi
AU - Ito, Koichi
AU - Ishiguro, Akira
N1 - Publisher Copyright:
© 2024 by The Japanese Society for Pediatric Endocrinology.
PY - 2024/1
Y1 - 2024/1
N2 - Complete deficiency of thyroxin-binding globulin (TBG-CD) is not commonly associated with clinical symptoms, and little is known about thyroid tumors associated with TBG-CD. We present a case report of an asymptomatic follicular adenoma that spontaneously shrank in a patient with TBG-CD. A previously healthy 13-yr-old male presented with a diffusely swollen thyroid gland. Thyroid function tests revealed low total thyroxin and TBG concentrations, indicating a TBG deficiency. Ultrasonography revealed a mildly swollen thyroid gland with a nodule (14 × 12 × 19 mm) in the left lobe. Genetic analysis of peripheral blood revealed a previously reported SERPINA7 variant, which resulted in complete loss of TBG function. The nodule was identified as a follicular adenoma using fine-needle aspiration. Subsequently, the adenoma shrank without treatment. This pubertal case suggests that careful observation with ultrasonography is warranted for follicular adenoma in patients with TBG deficiency and that treatment may not be required.
AB - Complete deficiency of thyroxin-binding globulin (TBG-CD) is not commonly associated with clinical symptoms, and little is known about thyroid tumors associated with TBG-CD. We present a case report of an asymptomatic follicular adenoma that spontaneously shrank in a patient with TBG-CD. A previously healthy 13-yr-old male presented with a diffusely swollen thyroid gland. Thyroid function tests revealed low total thyroxin and TBG concentrations, indicating a TBG deficiency. Ultrasonography revealed a mildly swollen thyroid gland with a nodule (14 × 12 × 19 mm) in the left lobe. Genetic analysis of peripheral blood revealed a previously reported SERPINA7 variant, which resulted in complete loss of TBG function. The nodule was identified as a follicular adenoma using fine-needle aspiration. Subsequently, the adenoma shrank without treatment. This pubertal case suggests that careful observation with ultrasonography is warranted for follicular adenoma in patients with TBG deficiency and that treatment may not be required.
KW - TBG deficiency
KW - thyroid adenoma
KW - thyroxin-binding globulin
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U2 - 10.1297/cpe.2023-0031
DO - 10.1297/cpe.2023-0031
M3 - Article
AN - SCOPUS:85184413441
SN - 0918-5739
VL - 33
SP - 23
EP - 26
JO - clinical pediatric endocrinology
JF - clinical pediatric endocrinology
IS - 1
ER -
