TY - JOUR
T1 - A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice
AU - Ogura, Akihiro
AU - Urano, Sayaka
AU - Tahara, Tsuyoshi
AU - Nozaki, Satoshi
AU - Sibgatullina, Regina
AU - Vong, Kenward
AU - Suzuki, Takehiro
AU - Dohmae, Naoshi
AU - Kurbangalieva, Almira
AU - Watanabe, Yasuyoshi
AU - Tanaka, Katsunori
N1 - Funding Information:
This work was supported by the JSPS KAKENHI Grant Number JP16H03287, JP16K13104, and JP15H05843 in the Middle Molecular Strategy. This work was also performed with the support of the Russian Government Program for Competitive Growth, granted to Kazan Federal University, and the support of a grant from JST PRESTO. The authors would also like to thank Glytech Inc. for supplying various N-glycans.
Publisher Copyright:
© 2018 The Royal Society of Chemistry.
PY - 2018
Y1 - 2018
N2 - This work represents the first broad study of testing diverse heterogenous glycoconjugates (7 different glycoalbumins) for their differential in vivo binding (11 different cancer cell types) in both cell- and animal-based studies. As a result, various changes in biodistribution, excretion, and even tumor adhesion were observed.
AB - This work represents the first broad study of testing diverse heterogenous glycoconjugates (7 different glycoalbumins) for their differential in vivo binding (11 different cancer cell types) in both cell- and animal-based studies. As a result, various changes in biodistribution, excretion, and even tumor adhesion were observed.
UR - http://www.scopus.com/inward/record.url?scp=85050922783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050922783&partnerID=8YFLogxK
U2 - 10.1039/c8cc01544a
DO - 10.1039/c8cc01544a
M3 - Article
C2 - 29956701
AN - SCOPUS:85050922783
SN - 1359-7345
VL - 54
SP - 8693
EP - 8696
JO - Chemical Communications
JF - Chemical Communications
IS - 63
ER -
