Acid-base titration using a microfluidic thread-based analytical device (μTAD)

Purim Jarujamrus, Akarapong Prakobkij, Sodsai Puchum, Sawida Chaisamdaeng, Rattapol Meelapsom, Wipark Anutrasakda, Maliwan Amatatongchai, Sanoe Chairam, Daniel Citterio

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


This work presents the development and application of a novel analytical approach for the determination of acid and base concentrations by titration using a microfluidic thread-based analytical device (μTAD). This approach proved to be a simple to fabricate and to use, high precision, and cost-efficient means of acid-base quantification. The μTAD was fabricated by immobilizing the untreated cotton threads onto a wood frame, followed by pre-coating with an indicator (20 μL) and a primary standard solution (3 μL), and was tested using real samples including drug, food, and household products where 3 μL of each sample was dropped onto the center of a thread. Afterward, the distance of color change on the thread, easily observed and measured using the naked eye and a ruler, was used for analysis. The analysis using the μTAD, completed within 2 minutes and validated by the conventional titration, showed high accuracy and precision (RSD < 12.9%), good linearity ranges and low limit of quantification. The fabricated μTAD also remained stable for an extended period of time (>2 weeks under various storage conditions).

Original languageEnglish
Pages (from-to)4457-4466
Number of pages10
Issue number13
Publication statusPublished - 2020 Jul 7

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry


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