TY - JOUR
T1 - Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features
AU - Kuroda, Naoto
AU - Tamura, Masato
AU - Hamaguchi, Nobumasa
AU - Mikami, Shuji
AU - Pan, Chin Chen
AU - Brunelli, Matteo
AU - Martignoni, Guido
AU - Hes, Ondrej
AU - Michal, Michal
AU - Lee, Gang Hong
PY - 2011/12
Y1 - 2011/12
N2 - Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently described entity. To the best of our knowledge, there are no reports of ACD-associated RCC with sarcomatoid and rhabdoid changes. In this article, we present the first case of such a tumor. A 56-year-old Japanese man has received long-term hemodialysis and had a history of right renal cancer. Following the discovery of metastatic cancer in the thoracic wall, detailed imaging studies revealed a mass in the left kidney. The histologic examination of the left renal tumor showed ACD-associated RCC with sarcomatoid change and rhabdoid features. Immunohistochemically, intracytoplasmic globular inclusions in rhabdoid cells were positive for vimentin and cytokeratin CAM5.2. The G-band karyotype showed the following changes: 46, X, +X. -Y[1]/43, idem, add(2)(q31), -6, -9, -14, -15, +16, -22, +mar1[6]/46, XY[2]/abnormal cell[11]. In conclusion, pathologists and urologists should be aware that rhabdoid features may occur in ACD-associated RCC and that the loss of chromosomes 9 and 14 may occur during the process of sarcomatoid change in ACD-associated RCC.
AB - Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently described entity. To the best of our knowledge, there are no reports of ACD-associated RCC with sarcomatoid and rhabdoid changes. In this article, we present the first case of such a tumor. A 56-year-old Japanese man has received long-term hemodialysis and had a history of right renal cancer. Following the discovery of metastatic cancer in the thoracic wall, detailed imaging studies revealed a mass in the left kidney. The histologic examination of the left renal tumor showed ACD-associated RCC with sarcomatoid change and rhabdoid features. Immunohistochemically, intracytoplasmic globular inclusions in rhabdoid cells were positive for vimentin and cytokeratin CAM5.2. The G-band karyotype showed the following changes: 46, X, +X. -Y[1]/43, idem, add(2)(q31), -6, -9, -14, -15, +16, -22, +mar1[6]/46, XY[2]/abnormal cell[11]. In conclusion, pathologists and urologists should be aware that rhabdoid features may occur in ACD-associated RCC and that the loss of chromosomes 9 and 14 may occur during the process of sarcomatoid change in ACD-associated RCC.
KW - Acquired cystic disease
KW - Renal cell carcinoma
KW - Rhabdoid features
KW - Sarcomatoid change
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UR - http://www.scopus.com/inward/citedby.url?scp=81155151396&partnerID=8YFLogxK
U2 - 10.1016/j.anndiagpath.2010.07.008
DO - 10.1016/j.anndiagpath.2010.07.008
M3 - Article
C2 - 21036640
AN - SCOPUS:81155151396
SN - 1092-9134
VL - 15
SP - 462
EP - 466
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
IS - 6
ER -
