Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant

Tomonori Nakamura; Emi Okuyama; Atsushi Tsukada; Mikio Yamazaki; Motoyoshi Satake; Sansei Nishibe; Takeshi Deyama; Akira Moriya; Masao Maruno; Hiroaki Nishimura

doi:10.1248/cpb.45.499

Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant

Tomonori Nakamura, Emi Okuyama, Atsushi Tsukada, Mikio Yamazaki, Motoyoshi Satake, Sansei Nishibe, Takeshi Deyama, Akira Moriya, Masao Maruno, Hiroaki Nishimura

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Acteoside (verbascoside) was isolated as an analgesic principle from Cedron (leaves and stem of Lippia triphylla (L'HER) O. KUNTZE; Verbenaceae), a Peruvian medicinal plant, by activity-guided separation. The compound exhibited analgesia on acetic acid-induced writhing and on tail pressure pain in mice by the oral administration of 300mg/kg and 100mg/kg, respectively. Acteoside also caused weak sedation by its effect on the prolongation of pentobarbital-induced anesthesia and on the depression of locomotion enhanced by methamphetamine. An intravenous injection of acteoside reduced the effective dose to 2mg/kg by the writhing method. Thirteen related compounds were tested for the activity by intravenous and oral administration to obtain information on the active structure.

Original language	English
Pages (from-to)	499-504
Number of pages	6
Journal	Chemical and Pharmaceutical Bulletin
Volume	45
Issue number	3
DOIs	https://doi.org/10.1248/cpb.45.499
Publication status	Published - 1997 Mar
Externally published	Yes

Keywords

Lippia triphylla
acteoside
analgesia
phenylethanoid glycoside
sedation

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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title = "Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant",

abstract = "Acteoside (verbascoside) was isolated as an analgesic principle from Cedron (leaves and stem of Lippia triphylla (L'HER) O. KUNTZE; Verbenaceae), a Peruvian medicinal plant, by activity-guided separation. The compound exhibited analgesia on acetic acid-induced writhing and on tail pressure pain in mice by the oral administration of 300mg/kg and 100mg/kg, respectively. Acteoside also caused weak sedation by its effect on the prolongation of pentobarbital-induced anesthesia and on the depression of locomotion enhanced by methamphetamine. An intravenous injection of acteoside reduced the effective dose to 2mg/kg by the writhing method. Thirteen related compounds were tested for the activity by intravenous and oral administration to obtain information on the active structure.",

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author = "Tomonori Nakamura and Emi Okuyama and Atsushi Tsukada and Mikio Yamazaki and Motoyoshi Satake and Sansei Nishibe and Takeshi Deyama and Akira Moriya and Masao Maruno and Hiroaki Nishimura",

year = "1997",

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doi = "10.1248/cpb.45.499",

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AU - Nakamura, Tomonori

AU - Okuyama, Emi

AU - Tsukada, Atsushi

AU - Yamazaki, Mikio

AU - Satake, Motoyoshi

AU - Nishibe, Sansei

AU - Deyama, Takeshi

AU - Moriya, Akira

AU - Maruno, Masao

AU - Nishimura, Hiroaki

PY - 1997/3

Y1 - 1997/3

N2 - Acteoside (verbascoside) was isolated as an analgesic principle from Cedron (leaves and stem of Lippia triphylla (L'HER) O. KUNTZE; Verbenaceae), a Peruvian medicinal plant, by activity-guided separation. The compound exhibited analgesia on acetic acid-induced writhing and on tail pressure pain in mice by the oral administration of 300mg/kg and 100mg/kg, respectively. Acteoside also caused weak sedation by its effect on the prolongation of pentobarbital-induced anesthesia and on the depression of locomotion enhanced by methamphetamine. An intravenous injection of acteoside reduced the effective dose to 2mg/kg by the writhing method. Thirteen related compounds were tested for the activity by intravenous and oral administration to obtain information on the active structure.

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KW - Lippia triphylla

KW - acteoside

KW - analgesia

KW - phenylethanoid glycoside

KW - sedation

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Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant

Abstract

Keywords

ASJC Scopus subject areas

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