Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant

Tomonori Nakamura, Emi Okuyama, Atsushi Tsukada, Mikio Yamazaki, Motoyoshi Satake, Sansei Nishibe, Takeshi Deyama, Akira Moriya, Masao Maruno, Hiroaki Nishimura

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)


Acteoside (verbascoside) was isolated as an analgesic principle from Cedron (leaves and stem of Lippia triphylla (L'HER) O. KUNTZE; Verbenaceae), a Peruvian medicinal plant, by activity-guided separation. The compound exhibited analgesia on acetic acid-induced writhing and on tail pressure pain in mice by the oral administration of 300mg/kg and 100mg/kg, respectively. Acteoside also caused weak sedation by its effect on the prolongation of pentobarbital-induced anesthesia and on the depression of locomotion enhanced by methamphetamine. An intravenous injection of acteoside reduced the effective dose to 2mg/kg by the writhing method. Thirteen related compounds were tested for the activity by intravenous and oral administration to obtain information on the active structure.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Issue number3
Publication statusPublished - 1997 Mar
Externally publishedYes


  • Lippia triphylla
  • acteoside
  • analgesia
  • phenylethanoid glycoside
  • sedation

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery


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