Activation of Neutrophil-like Cells Stimulated by Polymer Surfaces

Keiji Fujimoto, Jun Sasaki, Yoshihiro Tomida, Yoshiyuki Wakabayashi, Haruma Kawaguchi

Research output: Contribution to journalArticlepeer-review


Polymeric materials sometimes induce inflammatory response and tissue injury when they are clinically used. This preliminary study was carried out to elucidate the activation state of neutrophils non-specifically stimulated by the polymer materials. Sulfonation of polystyrene and graft polymerization of acrylamide, sodium styrenesulfonate, and N,N-dimethyl aminopropylacrylamide onto polyetherurethane were carried out. The amount of active oxygen from neutrophil-like cells in contact with these materials was measured for 7 min at 37°C. Activating agents were added to adhered cells 30 min after incubation. The first activation was dependent on the strength of the interaction between cells and the polymer surfaces. The second activation changed with the degree of the first activation and incubation time. These results suggest that the first stimulation partially induces cell activation; the stimulation is then stored, and is fired when cells are stimulated, and if not so fired, is eventually disposed of.

Original languageEnglish
Pages (from-to)367-371
Number of pages5
Issue number6
Publication statusPublished - 1998


  • Active Oxygen
  • Cell Activation
  • Graft Polymerization
  • Neutrophil
  • Sulfonated Polystyrene

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics


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