Acute interstitial nephritis associated with ulcerative colitis

Hirobumi Tokuyama, Shu Wakino, Konosuke Konishi, Akinori Hashiguchi, Koichi Hayashi, Hiroshi Itoh

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Although drugs used in inflammatory bowel diseases (IBD) cause renal injury, glomerulopathies may also accompany IBD. We report a case with the rare association of ulcerative colitis (UC) and acute progressive interstitial nephritis. Although the kidney is acknowledged as a target organ for injury as a result of drug nephrotoxicity, our findings lend support to the novel recognition that the deranged autoimmune system emerging in UC causes interstitial nephritis as an extraintestinal manifestation. Overt renal failure due to interstitial nephritis has rarely been reported in UC patients. The case presented here therefore provides novel information on UC-associated nephropathy.

Original languageEnglish
Pages (from-to)483-486
Number of pages4
JournalClinical and experimental nephrology
Issue number5
Publication statusPublished - 2010 Oct 1


  • Acute interstitial nephritis
  • CD3-positive T cell
  • Ulcerative colitis

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)


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