Advanced gallbladder cancer that showed complete response to gemcitabine plus S-1 chemotherapy

Maiko Takita, Eisuke Iwasaki, Ken Hatogai, Ryohei Kishino, Eri Seki, Motoko Izumiya, Norio Maeda, Atsushi Nakazawa, Akira Mizuki, Kan Handa, Yutaka Shimoyama, Kiyoshi Mukai, Hajime Higuchi, Hiromasa Takaishi, Toshifumi Hibi, Nobuhiro Tsukada

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3 Citations (Scopus)


A 57-year-old man with advanced gallbladder cancer and accompanying hepatic, colonic and duodenal invasion and para-aortic lymph node metastasis was referred to our hospital. Gemcitabine plus S-1 administration was chosen. Gemcitabine was administered intravenously at a dose of 1000mg/m 2 on days 1 and 15, and repeated every 4 weeks. S-1 was administered orally at a dose of 40mg/m 2 bid. on days 1-14. Chemotherapy was effective for the primary gallbladder tumor and lymph node metastasis. The primary tumor and metastatic lymph nodes were shown to have disappeared by a FDG-PET CT study after 10 courses of chemotherapy. Informed consent was obtained prior to performing surgery of the primary lesion. Pathological examination showed fibrosis and a small focus of residual cancer in the resected gallbladder. Complete resection was achieved as all the margins were negative. The findings suggest that gemcitabine plus S-1 treatment may be effective against advanced gallbladder cancer.

Original languageEnglish
Pages (from-to)1263-1270
Number of pages8
JournalJournal of Japanese Society of Gastroenterology
Issue number7
Publication statusPublished - 2011 Jul

ASJC Scopus subject areas

  • Gastroenterology


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