Advances in capillary electrophoresis mass spectrometry for metabolomics

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10 Citations (Scopus)

Abstract

Capillary electrophoresis mass spectrometry (CE-MS) is now regarded as a powerful tool for the comprehensive analysis of low-molecular-weight charged metabolites. Over the past decades, several CE-MS methods have been established and made significant contributions to metabolomics research in various areas. This review describes the general strategies and principles of the CE-MS-based metabolomics analyses, including sample preparation, CE separation modes, interfacing techniques, and mass spectrometers. Furthermore, new techniques to increase throughput ability in CE-MS for metabolomics are highlighted. Finally, general conclusions and perspectives are provided.

Original languageEnglish
Article number116883
JournalTrAC - Trends in Analytical Chemistry
Volume158
DOIs
Publication statusPublished - 2023 Jan

Keywords

  • Capillary electrophoresis
  • Mass spectrometry
  • Metabolome
  • Metabolomics
  • Multisegment injection
  • Sheath-flow
  • Sheathless

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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