Aerobic oxygenation of benzylic ketones promoted by a gold nanocluster catalyst

Hidehiro Sakurai, Ikuyo Kamiya, Hiroaki Kitahara, Hironori Tsunoyama, Tatsuya Tsukudad

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Gold nanoclusters stabilized by poly(N-vinyl-2-pyrrolidone) (Au:PVP) promote the oxidation of benzylic ketones, including auto-oxidation-type bond-cleavage reactions and α-hydroxylation, under ambient conditions. The catalyst accelerates the formation of an α-peroxide intermediate, from which bond cleavage spontaneously proceeds in aqueous solvent to give the auto-oxidation products. In contrast, the a-hydroxylation product is obtained predominantly in DMSO solvent.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
Issue number2
Publication statusPublished - 2009 Jan
Externally publishedYes


  • Auto-oxidation
  • Gold nanocluster
  • α-hydroxylation

ASJC Scopus subject areas

  • Organic Chemistry


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