Age-related changes in cortical bone in women: Metacarpal bone mass measurement study

Jun Iwamoto, Tsuyoshi Takeda, Toshiro Otani, Yutaka Yabe

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21 Citations (Scopus)


The mechanism of age-related cortical bone loss was investigated in 229 Japanese women, 41-94 years of age, by metacarpal bone mass measurement. While no significant correlation was found between bone width and age, a significant increase in bone marrow width, and significant decreases in cortical bone density and total bone mass were observed in association with aging (P < 0.0001). There was a significant negative correlation between total bone mass and bone marrow width (r = -0.239; P < 0.0005), and significant positive correlations between both total bone mass and cortical bone density (r = 0.539; P < 0.0001) and cortical bone width (r = 0.839; P < 0.0001). The findings suggested that age-related cortical bone loss in middle-aged and elderly women resulted from two different factors; a decrease in cortical bone density caused by progression of intracortical porosity, and a decrease in cortical bone width as a result of bone loss on the endosteal surface. The latter had a greater influence on an age-related cortical bone loss than the former.

Original languageEnglish
Pages (from-to)90-94
Number of pages5
JournalJournal of Orthopaedic Science
Issue number2
Publication statusPublished - 1998


  • Aging
  • Cortical bone
  • Women

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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