Aggrecanase analysis of synovial fluid of temporomandibular joint disorders

K. Yoshida; S. Takatsuka; A. Tanaka; E. Hatada; H. Nakamura; K. Nakagawa; Y. Okada

doi:10.1111/j.1601-0825.2005.01120.x

Aggrecanase analysis of synovial fluid of temporomandibular joint disorders

K. Yoshida, S. Takatsuka, A. Tanaka, E. Hatada, H. Nakamura, K. Nakagawa, Y. Okada

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

OBJECTIVES: To determine whether or not aggrecanase in synovial fluid can be used as a biochemical marker in the diagnosis of temporomandibular joint disorder (TMJD). MATERIALS AND METHODS: Forty-four samples of synovial fluid were obtained from 35 patients with internal derangement or osteoarthritis and 15 control samples from 1O asymptomatic volunteers. Aggrecanase in the synovial fluid was examined by immunoblotting. RESULT: The incidence of aggrecanase expression in TMJD group were significantly higher than that in the normal control group (P < 0.05). Those with severe OA and anterior disc displacement without reduction showed significantly high expression of aggrecanase compared with other disease subgroups (P < 0.05). CONCLUSION: These findings suggested that aggrecanase could be a potential biochemical marker for cartilage degeneration in the TMJD.

Original language	English
Pages (from-to)	299-302
Number of pages	4
Journal	Oral Diseases
Volume	11
Issue number	5
DOIs	https://doi.org/10.1111/j.1601-0825.2005.01120.x
Publication status	Published - 2005 Sept
Externally published	Yes

Keywords

Aggrecanase
Magnetic resonance imaging
Synovial fluid
Temporomandibular joint

ASJC Scopus subject areas

Otorhinolaryngology
Dentistry(all)

Access to Document

10.1111/j.1601-0825.2005.01120.x

Cite this

@article{23553682dda3407b842486d035706d9a,

title = "Aggrecanase analysis of synovial fluid of temporomandibular joint disorders",

abstract = "OBJECTIVES: To determine whether or not aggrecanase in synovial fluid can be used as a biochemical marker in the diagnosis of temporomandibular joint disorder (TMJD). MATERIALS AND METHODS: Forty-four samples of synovial fluid were obtained from 35 patients with internal derangement or osteoarthritis and 15 control samples from 1O asymptomatic volunteers. Aggrecanase in the synovial fluid was examined by immunoblotting. RESULT: The incidence of aggrecanase expression in TMJD group were significantly higher than that in the normal control group (P < 0.05). Those with severe OA and anterior disc displacement without reduction showed significantly high expression of aggrecanase compared with other disease subgroups (P < 0.05). CONCLUSION: These findings suggested that aggrecanase could be a potential biochemical marker for cartilage degeneration in the TMJD.",

keywords = "Aggrecanase, Magnetic resonance imaging, Synovial fluid, Temporomandibular joint",

author = "K. Yoshida and S. Takatsuka and A. Tanaka and E. Hatada and H. Nakamura and K. Nakagawa and Y. Okada",

year = "2005",

month = sep,

doi = "10.1111/j.1601-0825.2005.01120.x",

language = "English",

volume = "11",

pages = "299--302",

journal = "Oral Diseases",

issn = "1354-523X",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Aggrecanase analysis of synovial fluid of temporomandibular joint disorders

AU - Yoshida, K.

AU - Takatsuka, S.

AU - Tanaka, A.

AU - Hatada, E.

AU - Nakamura, H.

AU - Nakagawa, K.

AU - Okada, Y.

PY - 2005/9

Y1 - 2005/9

N2 - OBJECTIVES: To determine whether or not aggrecanase in synovial fluid can be used as a biochemical marker in the diagnosis of temporomandibular joint disorder (TMJD). MATERIALS AND METHODS: Forty-four samples of synovial fluid were obtained from 35 patients with internal derangement or osteoarthritis and 15 control samples from 1O asymptomatic volunteers. Aggrecanase in the synovial fluid was examined by immunoblotting. RESULT: The incidence of aggrecanase expression in TMJD group were significantly higher than that in the normal control group (P < 0.05). Those with severe OA and anterior disc displacement without reduction showed significantly high expression of aggrecanase compared with other disease subgroups (P < 0.05). CONCLUSION: These findings suggested that aggrecanase could be a potential biochemical marker for cartilage degeneration in the TMJD.

AB - OBJECTIVES: To determine whether or not aggrecanase in synovial fluid can be used as a biochemical marker in the diagnosis of temporomandibular joint disorder (TMJD). MATERIALS AND METHODS: Forty-four samples of synovial fluid were obtained from 35 patients with internal derangement or osteoarthritis and 15 control samples from 1O asymptomatic volunteers. Aggrecanase in the synovial fluid was examined by immunoblotting. RESULT: The incidence of aggrecanase expression in TMJD group were significantly higher than that in the normal control group (P < 0.05). Those with severe OA and anterior disc displacement without reduction showed significantly high expression of aggrecanase compared with other disease subgroups (P < 0.05). CONCLUSION: These findings suggested that aggrecanase could be a potential biochemical marker for cartilage degeneration in the TMJD.

KW - Aggrecanase

KW - Magnetic resonance imaging

KW - Synovial fluid

KW - Temporomandibular joint

UR - http://www.scopus.com/inward/record.url?scp=25144513074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25144513074&partnerID=8YFLogxK

U2 - 10.1111/j.1601-0825.2005.01120.x

DO - 10.1111/j.1601-0825.2005.01120.x

M3 - Article

C2 - 16120116

AN - SCOPUS:25144513074

SN - 1354-523X

VL - 11

SP - 299

EP - 302

JO - Oral Diseases

JF - Oral Diseases

IS - 5

ER -

Aggrecanase analysis of synovial fluid of temporomandibular joint disorders

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this