Aging of the hematopoietic stem cells niche

Ayako Nakamura-Ishizu; Toshio Suda

doi:10.1007/s12185-014-1641-8

Aging of the hematopoietic stem cells niche

Ayako Nakamura-Ishizu
, Toshio Suda

The Sakaguchi Laboratory of Developmental Biology Department of Cell Differentiation

Research output: Contribution to journal › Review article › peer-review

27 Citations (Scopus)

Abstract

Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.

Original language	English
Pages (from-to)	317-325
Number of pages	9
Journal	International Journal of Hematology
Volume	100
Issue number	4
DOIs	https://doi.org/10.1007/s12185-014-1641-8
Publication status	Published - 2014 Oct 9

Keywords

Aging
Bone marrow
Hematopoietic stem cells
Niche

ASJC Scopus subject areas

Hematology

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10.1007/s12185-014-1641-8

Cite this

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abstract = "Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.",

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AU - Suda, Toshio

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AB - Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.

KW - Aging

KW - Bone marrow

KW - Hematopoietic stem cells

KW - Niche

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UR - https://www.scopus.com/pages/publications/84927170343#tab=citedBy

U2 - 10.1007/s12185-014-1641-8

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M3 - Review article

C2 - 25096220

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Aging of the hematopoietic stem cells niche

Abstract

Keywords

ASJC Scopus subject areas

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