TY - JOUR
T1 - Alcohol dehydrogenase
T2 - A new sensitive marker of hepatic centrilobular damage
AU - Kato, Shinzo
AU - Ishii, Hiromasa
AU - Kano, Shojiro
AU - Hagihara, Sachiko
AU - Todoroki, Toru
AU - Nagata, Shigeyuki
AU - Takahashi, Hisao
AU - Shigeta, Yohsuke
AU - Tsuchiya, Masaharu
N1 - Funding Information:
~This study was partly supported by the grant of Ministry of Education of Japan. 2Requests for reprints should be addressed to Masaharu Tsuchiya, M.D., Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan.
PY - 1985
Y1 - 1985
N2 - To determine whether serum alcohol dehydrogenase (ADH) activity reflects hepatic damage of centrilobular region (zone 3), the rats were given either bromobenzene (BB) or allyl alcohol (AA) IP to produce the pericen tral or periportal necrosis respectively. After AA or BB serum alanine aminotransferase (ALT) activity showed no significant difference between the two groups. By contrast, serum ADH and glutamate dehydrogenase (GLDH) activities were elevated preferentially in the BB treated rats. However, AA administration to rats also resulted in a significant increase in GLDH activity, whereas ADH activity was only slightly elevated when compared to controls. Moreover, acute ethanol administration to rats resulted in a significant elevation of the serum ADH activity, whereas serum GLDH and ALT activities remained normal. These data suggest that serum ADH activity appears to be a sensitive and specific marker of hepatic centrilobular damage.
AB - To determine whether serum alcohol dehydrogenase (ADH) activity reflects hepatic damage of centrilobular region (zone 3), the rats were given either bromobenzene (BB) or allyl alcohol (AA) IP to produce the pericen tral or periportal necrosis respectively. After AA or BB serum alanine aminotransferase (ALT) activity showed no significant difference between the two groups. By contrast, serum ADH and glutamate dehydrogenase (GLDH) activities were elevated preferentially in the BB treated rats. However, AA administration to rats also resulted in a significant increase in GLDH activity, whereas ADH activity was only slightly elevated when compared to controls. Moreover, acute ethanol administration to rats resulted in a significant elevation of the serum ADH activity, whereas serum GLDH and ALT activities remained normal. These data suggest that serum ADH activity appears to be a sensitive and specific marker of hepatic centrilobular damage.
KW - Allyl alcohol
KW - Bromobenzene
KW - Ethanol
KW - Hepatic centrilobular damage
KW - Serum alcohol dehydrogenase
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U2 - 10.1016/0741-8329(85)90011-4
DO - 10.1016/0741-8329(85)90011-4
M3 - Article
C2 - 3160368
AN - SCOPUS:0022361984
SN - 0741-8329
VL - 2
SP - 35
EP - 38
JO - Alcohol
JF - Alcohol
IS - 1
ER -