TY - JOUR
T1 - Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma
AU - Kami, Masahiro
AU - Hamaki, Tamae
AU - Miyakoshi, Shigesaburo
AU - Murashige, Naoko
AU - Kanda, Yoshinobu
AU - Tanosaki, Ryuji
AU - Takaue, Yoichi
AU - Taniguchi, Shuichi
AU - Hirai, Hisamaru
AU - Ozawa, Keiya
AU - Kasai, Masaharu
PY - 2003/1
Y1 - 2003/1
N2 - The feasibility of allogeneic haematopoietic stem-cell transplantation (allo-HSCT) in 11 patients with adult T-cell leukaemia/lymphoma (ATL) (6 acute, 4 lymphoma, 1 chronic type) was evaluated. The preparative regimens (9 conventional, 2 reduced-intensity) were tolerable. Five patients developed acute graft-versus-host disease (GVHD), and three, extensive chronic GVHD. All 10 patients who survived > 30 d achieved complete remission. Estimated 1-year overall and disease-free survival rates were 53 ± 30% and 45 ± 29% respectively. Four patients remain alive and disease-free at a median follow-up of 25 months. The others died of transplantation-related complications. This pilot study suggests that allo-HSCT in ATL should be evaluated further.
AB - The feasibility of allogeneic haematopoietic stem-cell transplantation (allo-HSCT) in 11 patients with adult T-cell leukaemia/lymphoma (ATL) (6 acute, 4 lymphoma, 1 chronic type) was evaluated. The preparative regimens (9 conventional, 2 reduced-intensity) were tolerable. Five patients developed acute graft-versus-host disease (GVHD), and three, extensive chronic GVHD. All 10 patients who survived > 30 d achieved complete remission. Estimated 1-year overall and disease-free survival rates were 53 ± 30% and 45 ± 29% respectively. Four patients remain alive and disease-free at a median follow-up of 25 months. The others died of transplantation-related complications. This pilot study suggests that allo-HSCT in ATL should be evaluated further.
KW - Adult T-cell leukaemia/lymphoma
KW - Allogeneic haematopoietic stem-cell transplantation
KW - Graft-versus-host disease
KW - Graft-versus-leukaemia effect
KW - Regimen-related toxicity
UR - http://www.scopus.com/inward/record.url?scp=0037272683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037272683&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.2003.04054.x
DO - 10.1046/j.1365-2141.2003.04054.x
M3 - Article
C2 - 12542491
AN - SCOPUS:0037272683
SN - 0007-1048
VL - 120
SP - 304
EP - 309
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 2
ER -